PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31539632-5 2019 Our findings also showed that BKM120 augmented ATO-induced anti-proliferative effects through inducing G1 arrest and reducing the incorporation of BrdU into the synthesized DNA of drugs-treated cells, which was coupled with c-Myc-mediated suppression of hTERT expression. NVP-BKM120 30-36 telomerase reverse transcriptase Homo sapiens 254-259 29495002-0 2018 Synergistic Antitumor Effect of BKM120 with Prima-1Met Via Inhibiting PI3K/AKT/mTOR and CPSF4/hTERT Signaling and Reactivating Mutant P53. NVP-BKM120 32-38 telomerase reverse transcriptase Homo sapiens 94-99 29495002-10 2018 Consistently, overexpression of hTERT rescued the inhibitions of cell viability, invasion and stem-like traits mediated by the combination of BKM120 and Prima-1Met. NVP-BKM120 142-148 telomerase reverse transcriptase Homo sapiens 32-37 29495002-11 2018 CONCLUSION: Our results showed that the combination of BKM120 with Prima-1Met synergistically suppressed the growth of thyroid cancer cells and tumor xenografts via inhibiting PI3K/Akt/mTOR and CPSF4/hTERT signaling and reactivating mutant p53. NVP-BKM120 55-61 telomerase reverse transcriptase Homo sapiens 200-205