PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25736722-1 2015 A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. icariin 16-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 25736722-1 2015 A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. icariin 16-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 23227542-2 2012 The inhibitory effect of icariin on the activity of AChE was investigated by inhibition kinetics. icariin 25-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 23227542-4 2012 The results showed that icariin could potently inhibit the activity of AChE, the IC50 value was determined to be 3.50 x 10(-8) mol x L(-1), and the determined IC50 value to tacrine was 0.75 x 10(-8) mol x L(-1). icariin 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 23227542-5 2012 Kinetic analyses showed that icariin is a reversible and mixed type AChE inhibitor. icariin 29-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 23227542-7 2012 Icariin binds selectively to the AChE peripheral anionic site via hydrogen bonds and Van der Waals forces. icariin 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37