PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34038639-5 2021 Three compounds I-13e, I-13h, and I-13i exhibit remarkable potency in inhibiting RNA synthesis driven by SARS-CoV-2 RdRp and relatively low cytotoxicity. i-13e 16-21 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 116-120 34038639-6 2021 Among these three compounds, I-13e showed the strongest inhibition upon RNA synthesis driven by SARS-CoV-2 RdRp, the resistance to viral exoribonuclease activity and the inhibitory effect on the replication of CoV, thus holding potential of being drug candidate for treatment of SARS-CoV-2. i-13e 29-34 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 107-111