PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30665496-6	2019	In cultured cardiac fibroblasts, combined treatment with homocysteine and NaCl increased profibrotic and matrix gene expression and activation of PI3/Akt pathway; all these effects were attenuated by tolvaptan Vasopressin levels, gene expression and V2 receptor expression were increased in vivo and in vitro on exposure to profibrotic stimuli, and tolvaptan attenuated these in vivo and in vitro effects.	Tolvaptan	200-209	AKT serine/threonine kinase 1	Rattus norvegicus	150-153	
30203914-10	2018	These changes may be explained due to alterations in miR-21/Spry1/ERK/MMP-9, miR-21/PTEN/PI3K/AKT, and NF-kappaB pathways by tolvaptan.	Tolvaptan	125-134	AKT serine/threonine kinase 1	Rattus norvegicus	94-97	
31434432-11	2019	Conclusions: CIH induces significant atrial remodeling in this rat model, which can be attenuated by tolvaptan possibly through modulating miRNA-21/Spry1/ERK/MMP-9 and miRNA-21/PTEN/PI3K/AKT signaling pathways.	Tolvaptan	101-110	AKT serine/threonine kinase 1	Rattus norvegicus	187-190