PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22233204-2	2012	Non-renal elimination accounts for 70% of the total clearance of tofacitinib and the metabolism is primarily mediated by cytochrome P450 (CYP) 3A4.	tofacitinib	65-76	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	121-136	
22233204-12	2012	RESULTS: In vitro studies demonstrated low potential for CYP inhibition (IC(50) estimates tofacitinib > 30 microm), CYP3A4 mRNA induction (observed at tofacitinib concentrations >= 25 microm) and no effect on enzymatic activity of CYP substrates.	tofacitinib	90-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-60	
24464803-9	2014	Cytochrome P450 (P450) profiling indicated that tofacitinib was mainly metabolized by CYP3A4, with a smaller contribution from CYP2C19.	tofacitinib	48-59	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15	
22233204-2	2012	Non-renal elimination accounts for 70% of the total clearance of tofacitinib and the metabolism is primarily mediated by cytochrome P450 (CYP) 3A4.	tofacitinib	65-76	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	138-141