PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32198387-8	2020	The administration of ZD7288 reduced the immobility time and escape latency time in the forced swim test (FST) and water maze test (WMT) with a decreased level of HCN1, upregulated BDNF-mTOR signaling pathways in the PFC and Hip, and synaptic ultrastructure changes in the PFC.	ICI D2788	22-28	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	Rattus norvegicus	163-167	
26855147-7	2016	Moreover, the HCN1 expression is increased in the amygdala of rats with peripheral nerve injury and intra-amygdaloidal administration of the HCN channel inhibitor ZD7288 attenuates nociceptive behavior in these rats.	ICI D2788	163-169	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	Rattus norvegicus	14-18	
25813712-4	2015	Therefore, in the present study we used the mSNA model to investigate whether: (a) expression of HCN1-HCN3 channels is altered in L4 DRG neurons which, in the mSNA model, are essential for transmission of the evoked pain, and which contribute to chronic spontaneous pain, and (b) local (intraplantar) blockade of these HCN channels, with a specific blocker, ZD7288, attenuates chronic spontaneous pain and/or evoked pain in mSNA rats.	ICI D2788	358-364	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	Rattus norvegicus	97-101	
25970616-7	2015	Blocking HCN1 channels with ZD7288 in vivo evoked kinetic tremors in nontremulous TRMR rats.	ICI D2788	28-34	hyperpolarization-activated cyclic nucleotide-gated potassium channel 1	Rattus norvegicus	9-13