PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26007173-6	2015	The carnosic acid gamma-lactone derivatives 1-3 were the most active antiproliferative compounds of the series, with IC50 values in the range of 43.4-46.9 muM and 39.2-48.9 muM for MRC-5 and AGS cells, respectively.	salvin	4-17	latexin	Homo sapiens	155-158	
26007173-6	2015	The carnosic acid gamma-lactone derivatives 1-3 were the most active antiproliferative compounds of the series, with IC50 values in the range of 43.4-46.9 muM and 39.2-48.9 muM for MRC-5 and AGS cells, respectively.	salvin	4-17	latexin	Homo sapiens	173-176	
22511203-5	2012	Component analysis of these fractions revealed the diterpenes carnosol and carnosic acid as potential bioactive principles inhibiting mPGES-1 activity with IC(50) values of 5.0 muM.	salvin	75-88	latexin	Homo sapiens	177-180	
22828666-7	2012	At a low dose, 5 mug/ml (15 muM), carnosic acid activated the expression of 3 genes, induced through the presence of antioxidant response elements, including genes involved in glutathione biosynthesis (CYP4F3, GCLC) and transport (SLC7A11).	salvin	34-47	latexin	Homo sapiens	28-31	
22531045-5	2012	Measuring cellular ATP, carnosic acid showed a dose-dependent increase in hepatotoxicity with an EC(50) value of 94.8 +- 36.7 muM in three human hepatocyte donors without a concurrent increase in the apoptosis markers caspase-3/7.	salvin	24-37	latexin	Homo sapiens	126-129	
22531045-6	2012	In human liver microsomes, carnosic acid did not exhibit significant time-dependent inhibition for any of the cytochrome P450 enzymes investigated, although it did inhibit CYP2C9- and CYP3A4-catalyzed reactions with K(i) values of 9.2 and 4.3 muM, respectively.	salvin	27-40	latexin	Homo sapiens	243-246	
22531045-8	2012	At 10 muM, carnosic acid increased CYP2B6 enzyme activity 61.6 and 49.3% in two donors compared with phenobarbital, and it increased CYP3A enzyme activity 82.6 and 142% compared with rifampicin.	salvin	11-24	latexin	Homo sapiens	6-9	
22511203-6	2012	Using a human whole-blood assay as a robust cell-based model, carnosic acid, but not carnosol, blocked PGE(2) generation upon stimulation with lipopolysaccharide (IC(50) = 9.3 muM).	salvin	62-75	latexin	Homo sapiens	176-179