PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26007173-6 2015 The carnosic acid gamma-lactone derivatives 1-3 were the most active antiproliferative compounds of the series, with IC50 values in the range of 43.4-46.9 muM and 39.2-48.9 muM for MRC-5 and AGS cells, respectively. salvin 4-17 latexin Homo sapiens 155-158 26007173-6 2015 The carnosic acid gamma-lactone derivatives 1-3 were the most active antiproliferative compounds of the series, with IC50 values in the range of 43.4-46.9 muM and 39.2-48.9 muM for MRC-5 and AGS cells, respectively. salvin 4-17 latexin Homo sapiens 173-176 22828666-7 2012 At a low dose, 5 mug/ml (15 muM), carnosic acid activated the expression of 3 genes, induced through the presence of antioxidant response elements, including genes involved in glutathione biosynthesis (CYP4F3, GCLC) and transport (SLC7A11). salvin 34-47 latexin Homo sapiens 28-31 22531045-5 2012 Measuring cellular ATP, carnosic acid showed a dose-dependent increase in hepatotoxicity with an EC(50) value of 94.8 +- 36.7 muM in three human hepatocyte donors without a concurrent increase in the apoptosis markers caspase-3/7. salvin 24-37 latexin Homo sapiens 126-129 22531045-6 2012 In human liver microsomes, carnosic acid did not exhibit significant time-dependent inhibition for any of the cytochrome P450 enzymes investigated, although it did inhibit CYP2C9- and CYP3A4-catalyzed reactions with K(i) values of 9.2 and 4.3 muM, respectively. salvin 27-40 latexin Homo sapiens 243-246 22531045-8 2012 At 10 muM, carnosic acid increased CYP2B6 enzyme activity 61.6 and 49.3% in two donors compared with phenobarbital, and it increased CYP3A enzyme activity 82.6 and 142% compared with rifampicin. salvin 11-24 latexin Homo sapiens 6-9 22511203-5 2012 Component analysis of these fractions revealed the diterpenes carnosol and carnosic acid as potential bioactive principles inhibiting mPGES-1 activity with IC(50) values of 5.0 muM. salvin 75-88 latexin Homo sapiens 177-180 22511203-6 2012 Using a human whole-blood assay as a robust cell-based model, carnosic acid, but not carnosol, blocked PGE(2) generation upon stimulation with lipopolysaccharide (IC(50) = 9.3 muM). salvin 62-75 latexin Homo sapiens 176-179