PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23239002-0	2012	Synergism between carnosic acid and arsenic trioxide on induction of acute myeloid leukemia cell apoptosis is associated with modulation of PTEN/Akt signaling pathway.	salvin	18-31	AKT serine/threonine kinase 1	Homo sapiens	145-148	
33800129-0	2021	Carnosic Acid Induces Apoptosis and Inhibits Akt/mTOR Signaling in Human Gastric Cancer Cell Lines.	salvin	0-13	AKT serine/threonine kinase 1	Homo sapiens	45-48	
22453599-0	2012	Carnosic acid modulates Akt/IKK/NF-kappaB signaling by PP2A and induces intrinsic and extrinsic pathway mediated apoptosis in human prostate carcinoma PC-3 cells.	salvin	0-13	AKT serine/threonine kinase 1	Homo sapiens	24-27	
33800129-6	2021	Additionally, carnosic acid is found to inhibit the phosphorylation/activation of Akt and mTOR.	salvin	14-27	AKT serine/threonine kinase 1	Homo sapiens	82-85	
33800129-8	2021	In conclusion, carnosic acid exhibits antitumor activity against human gastric cancer cells via modulating the Akt-mTOR signaling pathway that plays a crucial role in gastric cancer cell proliferation and survival.	salvin	15-28	AKT serine/threonine kinase 1	Homo sapiens	111-114	
30820808-5	2019	Moreover, we disclosed that carnosic acid could suppress signal transducer and activator of transcription (STAT)1, STAT3, and protein kinase B (Akt) phosphorylation in IL-27-stimulated TR146 cells.	salvin	28-41	AKT serine/threonine kinase 1	Homo sapiens	144-147	
31631173-0	2019	Antiproliferative Activity of Carnosic Acid is Mediated via Inhibition of Cell Migration and Invasion, and Suppression of Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway.	salvin	30-43	AKT serine/threonine kinase 1	Homo sapiens	160-163	
31631173-2	2019	The primary objective of this research was to determine the anticancer potential of carnosic acid, a plant derived abietane diterpene, against human lung cancer cells, as well as to determine its effects on cell migration and invasion, apoptosis, and the PI3K/AKT/m-TOR signaling pathway.	salvin	84-97	AKT serine/threonine kinase 1	Homo sapiens	260-263	
31631173-5	2019	Western blot assay was used to study effects of carnosic acid on the PI3K/AKT/m-TOR signaling pathway.	salvin	48-61	AKT serine/threonine kinase 1	Homo sapiens	74-77	
31631173-9	2019	Finally, western blot assay revealed that carnosic acid also led to inhibition of the PI3K/AKT/m-TOR signaling pathway.	salvin	42-55	AKT serine/threonine kinase 1	Homo sapiens	91-94	
31631173-10	2019	CONCLUSIONS In conclusion, our results showed that Carnosic acid has the potential to inhibit cancer cell growth in A-549 lung cancer cells by activating apoptotic death, inhibiting cell migration and invasion and suppressing PI3K/AKT/m-TOR signaling pathway.	salvin	51-64	AKT serine/threonine kinase 1	Homo sapiens	231-234	
30820808-7	2019	In summary, carnosic acid could reduce CXCR3 ligands production in human oral epithelial cell by inhibiting STAT1, STAT3, and Akt activation.	salvin	12-25	AKT serine/threonine kinase 1	Homo sapiens	126-129	
26577515-0	2015	Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells.	salvin	74-87	AKT serine/threonine kinase 1	Homo sapiens	18-21	
27435046-0	2016	Carnosic acid protects starvation-induced SH-SY5Y cell death through Erk1/2 and Akt pathways, autophagy, and FoxO3a.	salvin	0-13	AKT serine/threonine kinase 1	Homo sapiens	80-83	
27942213-0	2016	Upregulation of Akt/NF-kappaB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle.	salvin	155-168	AKT serine/threonine kinase 1	Homo sapiens	16-19	
27942213-0	2016	Upregulation of Akt/NF-kappaB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle.	salvin	155-168	AKT serine/threonine kinase 1	Homo sapiens	57-60	
25265205-0	2015	Carnosic acid induces apoptosis associated with mitochondrial dysfunction and Akt inactivation in HepG2 cells.	salvin	0-13	AKT serine/threonine kinase 1	Homo sapiens	78-81	
25178877-0	2015	Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells.	salvin	0-13	AKT serine/threonine kinase 1	Homo sapiens	70-73