PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28288941-6	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, increased hPXR target gene expression, as shown by an increase in CYP3A4, UGT1A3, and ABCB1 mRNA expression in LS180 human colon adenocarcinoma cells.	salvin	0-13	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	134-140	
22531045-6	2012	In human liver microsomes, carnosic acid did not exhibit significant time-dependent inhibition for any of the cytochrome P450 enzymes investigated, although it did inhibit CYP2C9- and CYP3A4-catalyzed reactions with K(i) values of 9.2 and 4.3 muM, respectively.	salvin	27-40	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	184-190	
22531045-7	2012	Carnosic acid also induced CYP2B6 and CYP3A4 mRNA and enzyme activity in a dose-dependent manner.	salvin	0-13	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	38-44	
22531045-8	2012	At 10 muM, carnosic acid increased CYP2B6 enzyme activity 61.6 and 49.3% in two donors compared with phenobarbital, and it increased CYP3A enzyme activity 82.6 and 142% compared with rifampicin.	salvin	11-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	133-138