PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20661831-7 2010 Caspase-8 inhibition abrogated Bid cleavage and strongly reduced caspase-9 activation, suggesting that the cross-talk mechanism mediated by caspase-8-dependent Bid cleavage can contribute to the activation of the intrinsic apoptotic pathway by curcumin + carnosic acid. salvin 255-268 caspase 9 Homo sapiens 65-74 20661831-5 2010 Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak). salvin 24-37 caspase 9 Homo sapiens 112-121 18652763-3 2008 Carnosic acid also augmented these effects when induced by a low (physiological) concentration of arsenic trioxide, which was associated with upregulation of p27 and activation of caspase-9. salvin 0-13 caspase 9 Homo sapiens 180-189