PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25596735-0	2015	Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells.	salvin	0-13	BCL2 apoptosis regulator	Homo sapiens	88-93	
35608363-10	2022	Acetyl royleanone, 6,7-dehydroroyleanone, carnosic acid, and cryptotanshinone were found to have anticancer potential based on their modulating effects on the expression levels of Bax and Bcl-2 proteins which play important roles in the regulation of apoptosis.	salvin	42-55	BCL2 apoptosis regulator	Homo sapiens	188-193	
25596735-4	2015	Carnosic acid induced down-regulation of c-FLIP and Bcl-2 expression at the post-translational levels, and the over-expression of c-FLIP and Bcl-2 markedly blocked carnosic acid-induced TRAIL sensitization.	salvin	164-177	BCL2 apoptosis regulator	Homo sapiens	141-146	
25596735-5	2015	Furthermore, carnosic acid induced death receptor (DR)5, Bcl-2 interacting mediator of cell death (Bim), and p53 up-regulated modulator of apoptosis (PUMA) expression at the transcriptional levels via CCAAT/enhancer-binding protein-homologous protein (CHOP).	salvin	13-26	BCL2 apoptosis regulator	Homo sapiens	57-62	
25596735-7	2015	Taken together, our study demonstrates that carnosic acid enhances sensitization against TRAIL-mediated apoptosis through the down-regulation of c-FLIP and Bcl-2 expression, and up-regulation of ER stress-mediated DR5, Bim, and PUMA expression at the transcriptional levels.	salvin	44-57	BCL2 apoptosis regulator	Homo sapiens	156-161	
30227824-8	2019	Administration of Trolox, carnosic acid and HCG increased the number of healthy cells and decreased the expression of Caspase-3 and Bax, but significantly increased the expression of Bcl-2 compared to the ischemic group.	salvin	26-39	BCL2 apoptosis regulator	Homo sapiens	183-188	
29285102-10	2017	Furthermore, the apoptosis of H9c2 cardiomyocytes resulted from hypoxia/reoxygenation was inhibited by carnosic acid through the upregulation of Bcl-2 and the downregulation of Bax and caspase-3 levels.	salvin	103-116	BCL2 apoptosis regulator	Homo sapiens	145-150	
28440400-7	2017	Caspase-3 signaling pathway was promoted in carnosic acid and fisetin co-treatment, which was accompanied by anti-apoptotic proteins of Bcl-2 and Bcl-xl decreasing and pro-apoptotic signals of Bax and Bad increasing.	salvin	44-57	BCL2 apoptosis regulator	Homo sapiens	136-141	
25596735-4	2015	Carnosic acid induced down-regulation of c-FLIP and Bcl-2 expression at the post-translational levels, and the over-expression of c-FLIP and Bcl-2 markedly blocked carnosic acid-induced TRAIL sensitization.	salvin	0-13	BCL2 apoptosis regulator	Homo sapiens	52-57	
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	salvin	24-37	BCL2 apoptosis regulator	Homo sapiens	228-233	
20661831-5	2010	Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak).	salvin	24-37	BCL2 apoptosis regulator	Homo sapiens	251-256