PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25596735-0 2015 Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells. salvin 0-13 BCL2 apoptosis regulator Homo sapiens 88-93 35608363-10 2022 Acetyl royleanone, 6,7-dehydroroyleanone, carnosic acid, and cryptotanshinone were found to have anticancer potential based on their modulating effects on the expression levels of Bax and Bcl-2 proteins which play important roles in the regulation of apoptosis. salvin 42-55 BCL2 apoptosis regulator Homo sapiens 188-193 25596735-4 2015 Carnosic acid induced down-regulation of c-FLIP and Bcl-2 expression at the post-translational levels, and the over-expression of c-FLIP and Bcl-2 markedly blocked carnosic acid-induced TRAIL sensitization. salvin 164-177 BCL2 apoptosis regulator Homo sapiens 141-146 25596735-5 2015 Furthermore, carnosic acid induced death receptor (DR)5, Bcl-2 interacting mediator of cell death (Bim), and p53 up-regulated modulator of apoptosis (PUMA) expression at the transcriptional levels via CCAAT/enhancer-binding protein-homologous protein (CHOP). salvin 13-26 BCL2 apoptosis regulator Homo sapiens 57-62 25596735-7 2015 Taken together, our study demonstrates that carnosic acid enhances sensitization against TRAIL-mediated apoptosis through the down-regulation of c-FLIP and Bcl-2 expression, and up-regulation of ER stress-mediated DR5, Bim, and PUMA expression at the transcriptional levels. salvin 44-57 BCL2 apoptosis regulator Homo sapiens 156-161 30227824-8 2019 Administration of Trolox, carnosic acid and HCG increased the number of healthy cells and decreased the expression of Caspase-3 and Bax, but significantly increased the expression of Bcl-2 compared to the ischemic group. salvin 26-39 BCL2 apoptosis regulator Homo sapiens 183-188 29285102-10 2017 Furthermore, the apoptosis of H9c2 cardiomyocytes resulted from hypoxia/reoxygenation was inhibited by carnosic acid through the upregulation of Bcl-2 and the downregulation of Bax and caspase-3 levels. salvin 103-116 BCL2 apoptosis regulator Homo sapiens 145-150 28440400-7 2017 Caspase-3 signaling pathway was promoted in carnosic acid and fisetin co-treatment, which was accompanied by anti-apoptotic proteins of Bcl-2 and Bcl-xl decreasing and pro-apoptotic signals of Bax and Bad increasing. salvin 44-57 BCL2 apoptosis regulator Homo sapiens 136-141 25596735-4 2015 Carnosic acid induced down-regulation of c-FLIP and Bcl-2 expression at the post-translational levels, and the over-expression of c-FLIP and Bcl-2 markedly blocked carnosic acid-induced TRAIL sensitization. salvin 0-13 BCL2 apoptosis regulator Homo sapiens 52-57 20661831-5 2010 Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak). salvin 24-37 BCL2 apoptosis regulator Homo sapiens 228-233 20661831-5 2010 Early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein Bid, but not with oxidative stress or altered levels of other Bcl-2 family proteins (Bcl-2, Bcl-xl, Mcl-1, Bax, and Bak). salvin 24-37 BCL2 apoptosis regulator Homo sapiens 251-256