PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34335271-11 2021 In vitro, melatonin pretreatment reversed Erastin-induced ferroptosis, abnormalities in iron transporter protein and antioxidant enzyme expression and suppression of ERK/Nrf2 signaling in HT-22 cells, however this protective effect of melatonin was blocked by MT2-, ERK- and Nrf2-specific antagonists (p < 0.05). erastin 42-49 mitogen-activated protein kinase 1 Mus musculus 166-169