PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34707002-13 2021 A peroxisome proliferation-activated receptor gamma (PPARgamma) blocker was used to observe the effect of 8,9-EET on erastin-induced glutathione peroxidase 4 (GPX4) and MDA content in PANC-1 cells. erastin 117-124 glutathione peroxidase 4 Homo sapiens 133-157 34903297-7 2021 Glutathione peroxidase 4 (GPX4) expression was decreased in IB3-1 cells treated with FAC and erastin, but was unchanged in C38 AECs. erastin 93-100 glutathione peroxidase 4 Homo sapiens 0-24 34903297-7 2021 Glutathione peroxidase 4 (GPX4) expression was decreased in IB3-1 cells treated with FAC and erastin, but was unchanged in C38 AECs. erastin 93-100 glutathione peroxidase 4 Homo sapiens 26-30 34648917-9 2022 Moreover, the forced expression of GPX4 abrogated ferroptosis induced by the combined treatment of Everolimus and RSL3/Erastin. erastin 119-126 glutathione peroxidase 4 Homo sapiens 35-39 34707002-13 2021 A peroxisome proliferation-activated receptor gamma (PPARgamma) blocker was used to observe the effect of 8,9-EET on erastin-induced glutathione peroxidase 4 (GPX4) and MDA content in PANC-1 cells. erastin 117-124 glutathione peroxidase 4 Homo sapiens 159-163 31160087-8 2019 Mechanistic studies revealed that erastin-induced ferroptosis is associated with GPX4 downregulation and ACSL4 upregulation. erastin 34-41 glutathione peroxidase 4 Homo sapiens 81-85 35325945-9 2022 In TU212 cells treated with erastin, mitochondrial crest became smaller, membrane density increased, proliferation rate decreased, intracellular ROS level increased, mitochondrial membrane potential depolarized, GSH content decreased, intracellular MDA level increased and expressions of GPX4 mRNA and protein decreased. erastin 28-35 glutathione peroxidase 4 Homo sapiens 288-292 35325945-11 2022 When erastin-treated TU212 cells were incubated with M2-exos, cell proliferation was partially restored and GPX4 expression was enhanced, and also with the recoveries of levels of ROS, MDA and GSH (all P<0.05). erastin 5-12 glutathione peroxidase 4 Homo sapiens 108-112 33609745-0 2021 Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression. erastin 69-76 glutathione peroxidase 4 Homo sapiens 109-133 33609745-10 2021 Our data indicated SRSF9"s regulation of GPX4 as an essential mechanism driving CRC tumorigenesis and resistance of erastin-induced ferroptosis. erastin 116-123 glutathione peroxidase 4 Homo sapiens 41-45 33730930-9 2021 Levels of ACSL4, SLC7A11, and GPX4 were decreased more by NEAT1 silencing plus erastin than by erastin alone. erastin 79-86 glutathione peroxidase 4 Homo sapiens 30-34 33730930-9 2021 Levels of ACSL4, SLC7A11, and GPX4 were decreased more by NEAT1 silencing plus erastin than by erastin alone. erastin 95-102 glutathione peroxidase 4 Homo sapiens 30-34 32984038-17 2020 Erastin could further decrease the activity of GPX4 compared with the decitabine group. erastin 0-7 glutathione peroxidase 4 Homo sapiens 47-51 31140862-5 2019 The levels of reactive oxygen species (ROS), malondialdehyde were increased, and the levels of GPX4 mRNA and protein were reduced after treatment with TGF-beta1, and all these were magnified after TGF-beta1+erastin treatment. erastin 207-214 glutathione peroxidase 4 Homo sapiens 95-99 31140862-8 2019 Collectively, our study reveals that ROS, lipid peroxidation, and GPX4 play important roles in pulmonary fibrosis and ferroptosis induced by erastin. erastin 141-148 glutathione peroxidase 4 Homo sapiens 66-70 30854078-0 2019 Erastin decreases radioresistance of NSCLC cells partially by inducing GPX4-mediated ferroptosis. erastin 0-7 glutathione peroxidase 4 Homo sapiens 71-75 30854078-10 2019 Erastin-induced and GPX4-inhibition-induced cell death could partially be rescued by deferoxamine, but not Z-VAD-FMK and olaparib, which indicated that erastin and GPX4-inhibition induced ferroptosis in the radioresistant cells. erastin 0-7 glutathione peroxidase 4 Homo sapiens 164-168 30854078-10 2019 Erastin-induced and GPX4-inhibition-induced cell death could partially be rescued by deferoxamine, but not Z-VAD-FMK and olaparib, which indicated that erastin and GPX4-inhibition induced ferroptosis in the radioresistant cells. erastin 152-159 glutathione peroxidase 4 Homo sapiens 20-24 30718432-7 2019 Furthermore, we showed that the activation of ferroptosis by erastin increased the levels of lysosome-associated membrane protein 2a to promote chaperone-mediated autophagy (CMA), which, in turn, promoted the degradation of GPX4. erastin 61-68 glutathione peroxidase 4 Homo sapiens 224-228 29852199-7 2018 RESULTS: Significant reduction in gene expression of GPX4, elevated expression of Nrf2 downstream targets, and expression profiles mirroring erastin-inhibition of Cystine/Glutamate Antiporter-System XC activity in psoriatic skin lesions, compared to both noninvolved skin and healthy patient samples, suggest an innately inducible mechanism of ferroptosis. erastin 141-148 glutathione peroxidase 4 Homo sapiens 53-57 30535490-12 2019 During GPX4 knockdown, ROS accumulation was promoted following oxidative stress exposure to either H2O2 or erastin. erastin 107-114 glutathione peroxidase 4 Homo sapiens 7-11 28972104-1 2017 Increases in lipid peroxidation can cause ferroptosis, a form of cell death triggered by inhibition of glutathione peroxidase 4 (GPX4), which catalyzes the reduction of lipid peroxides and is a target of ferroptosis inducers, such as erastin. erastin 234-241 glutathione peroxidase 4 Homo sapiens 103-127 28972104-1 2017 Increases in lipid peroxidation can cause ferroptosis, a form of cell death triggered by inhibition of glutathione peroxidase 4 (GPX4), which catalyzes the reduction of lipid peroxides and is a target of ferroptosis inducers, such as erastin. erastin 234-241 glutathione peroxidase 4 Homo sapiens 129-133