PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27588473-3 2016 We show that RSL3, a glutathione (GSH) peroxidase (GPX) 4 inhibitor, or Erastin, an inhibitor of the cystine/glutamate antiporter, cooperate with the Smac mimetic BV6 to induce reactive oxygen species (ROS)-dependent cell death in acute lymphoblastic leukemia (ALL) cells. erastin 72-79 diablo IAP-binding mitochondrial protein Homo sapiens 150-154 26774450-3 2016 Here, we report that pharmacological inhibitors of key pathways for the elimination of ROS, i.e. Erastin, buthionine sulfoximine (BSO) and Auranofin, sensitize ALL cells for cell death upon treatment with the Smac mimetic LCL161 that antagonizes Inhibitor of Apoptosis (IAP) proteins. erastin 97-104 diablo IAP-binding mitochondrial protein Homo sapiens 209-213