PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32028757-10	2020	In addition, structural changes caused by stress and blocking the changes by imipramine were corelated well with altered activation and expression of synaptic plasticity-promoting molecules such as phospho-CREB, phospho-CAMKII, and PSD-95.	Imipramine	77-87	cAMP responsive element binding protein 1	Mus musculus	206-210	
20122921-2	2010	Recently, chronic psychosocial stress as animal model of depression has been shown to stimulate CREB transcriptional activity in the brain; this stimulation was prevented by treatment with the antidepressant imipramine, which inhibits both noradrenaline and serotonin reuptake.	Imipramine	208-218	cAMP responsive element binding protein 1	Mus musculus	96-100	
24036107-7	2014	Co-administration of 9h of fasting and imipramine (30mg/kg, i.p) produced the additive antidepressant-like effects in the FST and increased the ratio of p-CREB/CREB.	Imipramine	39-49	cAMP responsive element binding protein 1	Mus musculus	155-159	
24036107-7	2014	Co-administration of 9h of fasting and imipramine (30mg/kg, i.p) produced the additive antidepressant-like effects in the FST and increased the ratio of p-CREB/CREB.	Imipramine	39-49	cAMP responsive element binding protein 1	Mus musculus	160-164	
26481532-4	2015	OBJECTIVE AND METHODS: In the present study we investigated whether acute or chronic treatment with imipramine, escitalopram, reboxetine and bupropion would cause changes in CREB, BDNF, TrkB and GPR39-Zn(2+) receptor proteins (measured by Western Blot) in the frontal cortex of mice fed with a low-zinc diet.	Imipramine	100-110	cAMP responsive element binding protein 1	Mus musculus	174-178	
23816950-1	2013	UNLABELLED: The effect of long-term administration of imipramine, a tricyclic antidepressant, on the phosphorylation status of cyclic adenosine monophosphate-responsive element-binding protein (CREB), mitogen-activated protein kinase family members, and phospholipase gamma-1 (PLCgamma-1) was investigated in the dorsal horn of the spinal cord following peripheral nerve lesion.	Imipramine	54-64	cAMP responsive element binding protein 1	Mus musculus	127-192	
23816950-1	2013	UNLABELLED: The effect of long-term administration of imipramine, a tricyclic antidepressant, on the phosphorylation status of cyclic adenosine monophosphate-responsive element-binding protein (CREB), mitogen-activated protein kinase family members, and phospholipase gamma-1 (PLCgamma-1) was investigated in the dorsal horn of the spinal cord following peripheral nerve lesion.	Imipramine	54-64	cAMP responsive element binding protein 1	Mus musculus	194-198	
23816950-6	2013	Moreover, imipramine therapy reversed nerve injury-induced CREB and PLCgamma-1 phosphorylation but had no effect on ERK1,2, p38, and c-Jun N-terminal kinase activity.	Imipramine	10-20	cAMP responsive element binding protein 1	Mus musculus	59-63	
23816950-9	2013	Our data also provide evidence that prolonged imipramine treatment may induce antinociception in neuropathic pain conditions because of its action on the PLCgamma-1/CREB-signaling pathway.	Imipramine	46-56	cAMP responsive element binding protein 1	Mus musculus	165-169	
17487276-8	2007	Treatment of the stressed mice with the antidepressant imipramine normalized luciferase expression to control levels in all brain regions and likewise reduced CREB-phosphorylation.	Imipramine	55-65	cAMP responsive element binding protein 1	Mus musculus	159-163	
16519925-6	2006	Repeated treatment with antidepressant drugs, imipramine (Imi) and fluoxetine (Flu), significantly reduced the plasma corticosterone concentration and enhanced the BDNF and CREB levels.	Imipramine	46-56	cAMP responsive element binding protein 1	Mus musculus	173-177	
16519925-6	2006	Repeated treatment with antidepressant drugs, imipramine (Imi) and fluoxetine (Flu), significantly reduced the plasma corticosterone concentration and enhanced the BDNF and CREB levels.	Imipramine	58-61	cAMP responsive element binding protein 1	Mus musculus	173-177