PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21354245-0	2011	Imipramine activates glial cell line-derived neurotrophic factor via early growth response gene 1 in astrocytes.	Imipramine	0-10	glial cell line derived neurotrophic factor	Mus musculus	21-64	
21354245-2	2011	The present study explored early growth response 1 (EGR-1) transcriptional regulation of imipramine-induced glial cell line-derived neurotrophic factor (GDNF) expression in astrocytes.	Imipramine	89-99	glial cell line derived neurotrophic factor	Mus musculus	108-151	
21354245-2	2011	The present study explored early growth response 1 (EGR-1) transcriptional regulation of imipramine-induced glial cell line-derived neurotrophic factor (GDNF) expression in astrocytes.	Imipramine	89-99	glial cell line derived neurotrophic factor	Mus musculus	153-157	
21354245-4	2011	The dose-dependent upregulation of EGR-1 by imipramine, the activation of GDNF by the over-expression of EGR-1 without imipramine and the reduction in the imipramine-induced GDNF mRNA expression after silencing of endogenous EGR-1 demonstrated that EGR-1 is upregulated by imipramine to activate the GDNF promoter.	Imipramine	119-129	glial cell line derived neurotrophic factor	Mus musculus	74-78	
21354245-4	2011	The dose-dependent upregulation of EGR-1 by imipramine, the activation of GDNF by the over-expression of EGR-1 without imipramine and the reduction in the imipramine-induced GDNF mRNA expression after silencing of endogenous EGR-1 demonstrated that EGR-1 is upregulated by imipramine to activate the GDNF promoter.	Imipramine	119-129	glial cell line derived neurotrophic factor	Mus musculus	74-78	
21354245-4	2011	The dose-dependent upregulation of EGR-1 by imipramine, the activation of GDNF by the over-expression of EGR-1 without imipramine and the reduction in the imipramine-induced GDNF mRNA expression after silencing of endogenous EGR-1 demonstrated that EGR-1 is upregulated by imipramine to activate the GDNF promoter.	Imipramine	119-129	glial cell line derived neurotrophic factor	Mus musculus	74-78	
21354245-5	2011	Furthermore, imipramine-induced GDNF mRNA expression was strongly attenuated in primary astrocytes from Egr-1(-/-) mice, and the immunoreactivity to an anti-GDNF antibody in glial fibrillary acidic protein-positive cells was lower in imipramine-treated astrocytes from Egr-1(-/-) mice than in those from Egr-1(+/-) mice.	Imipramine	13-23	glial cell line derived neurotrophic factor	Mus musculus	32-36	
21354245-5	2011	Furthermore, imipramine-induced GDNF mRNA expression was strongly attenuated in primary astrocytes from Egr-1(-/-) mice, and the immunoreactivity to an anti-GDNF antibody in glial fibrillary acidic protein-positive cells was lower in imipramine-treated astrocytes from Egr-1(-/-) mice than in those from Egr-1(+/-) mice.	Imipramine	13-23	glial cell line derived neurotrophic factor	Mus musculus	157-161	
21354245-5	2011	Furthermore, imipramine-induced GDNF mRNA expression was strongly attenuated in primary astrocytes from Egr-1(-/-) mice, and the immunoreactivity to an anti-GDNF antibody in glial fibrillary acidic protein-positive cells was lower in imipramine-treated astrocytes from Egr-1(-/-) mice than in those from Egr-1(+/-) mice.	Imipramine	234-244	glial cell line derived neurotrophic factor	Mus musculus	32-36	
21354245-5	2011	Furthermore, imipramine-induced GDNF mRNA expression was strongly attenuated in primary astrocytes from Egr-1(-/-) mice, and the immunoreactivity to an anti-GDNF antibody in glial fibrillary acidic protein-positive cells was lower in imipramine-treated astrocytes from Egr-1(-/-) mice than in those from Egr-1(+/-) mice.	Imipramine	234-244	glial cell line derived neurotrophic factor	Mus musculus	157-161	
21354245-8	2011	In conclusion, we found that imipramine induction of EGR-1 upregulated GDNF in astrocytes in a dose-dependent manner.	Imipramine	29-39	glial cell line derived neurotrophic factor	Mus musculus	71-75