PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20680307-9	2010	Imipramine and NOE also restored State 3 respiration to 248.4 +- 2 and 249.0 +- 2, respectively (p < 0.01 vs. TNFalpha alone).	Imipramine	0-10	tumor necrosis factor	Mus musculus	113-121	
22803040-5	2011	Ladasten was more potent than imipramine in decreasing the content of proinflammatory cytokines TNF-alpha and IL-6 and preventing the development of behavioral disturbances in mice.	Imipramine	30-40	tumor necrosis factor	Mus musculus	96-105	
22177663-7	2012	The lipopolysaccharide-induced release of tumor necrosis factor-alpha was inhibited by imipramine at concentrations comparable to those inhibiting the proton current.	Imipramine	87-97	tumor necrosis factor	Mus musculus	42-69	
19787068-14	2009	Induction of MMP-1 by TNF or IL-1beta is completely blocked by inhibition of ASM with imipramine.	Imipramine	86-96	tumor necrosis factor	Mus musculus	22-25	
25701613-10	2015	Following ex vivo LPS stimulation, microglia from mice exposed to RSD, had higher mRNA expression of IL-6, TNF-alpha, and IL-1beta, and this was reversed by imipramine treatment.	Imipramine	157-167	tumor necrosis factor	Mus musculus	107-116	
19889791-0	2010	Imipramine, in part through tumor necrosis factor alpha inhibition, prevents cognitive decline and beta-amyloid accumulation in a mouse model of Alzheimer"s disease.	Imipramine	0-10	tumor necrosis factor	Mus musculus	28-55	
19889791-9	2010	Imipramine significantly prevented memory deficits caused by Abeta25-35 in the water-maze and Y-maze tests, and inhibited the TNF-alpha increase in the frontal cortex.	Imipramine	0-10	tumor necrosis factor	Mus musculus	126-135	
19889791-11	2010	So, imipramine prevents memory impairment through its intrinsic property to inhibit TNF-alpha and Abeta accumulation and may represent a potential candidate for AD treatment.	Imipramine	4-14	tumor necrosis factor	Mus musculus	84-93	
22177663-8	2012	These results support the hypothesis that tumor necrosis factor-alpha inhibition by imipramine is related to its inhibitory effects on proton channels.	Imipramine	84-94	tumor necrosis factor	Mus musculus	42-69