PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6317800-5	1983	Lesioning of the dorsal noradrenergic bundle blocks the decline in beta-receptor number and activity produced by the ACTH-imipramine treatment.	Imipramine	122-132	proopiomelanocortin	Homo sapiens	117-121	
19762159-7	2010	RESULTS: Endogenous depressed patients in remission and currently receiving treatment with imipramine (mean length of treatment 145 days, SD=27) presented significantly lower buspirone responses to ACTH and cortisol than in the pre-treatment condition (Deltamax p< or =.05; AUC p<.001) and to ACTH in comparison with healthy controls (Deltamax p<.01; AUC p<.05).	Imipramine	91-101	proopiomelanocortin	Homo sapiens	198-202	
19762159-7	2010	RESULTS: Endogenous depressed patients in remission and currently receiving treatment with imipramine (mean length of treatment 145 days, SD=27) presented significantly lower buspirone responses to ACTH and cortisol than in the pre-treatment condition (Deltamax p< or =.05; AUC p<.001) and to ACTH in comparison with healthy controls (Deltamax p<.01; AUC p<.05).	Imipramine	91-101	proopiomelanocortin	Homo sapiens	299-303	
12089903-6	2002	The reduction of immobility, induced by the chronic administration of imipramine for 15 days, was blocked by treatment with ACTH for 14 days.	Imipramine	70-80	proopiomelanocortin	Homo sapiens	124-128	
23276607-4	2013	Herein, we demonstrate that ACTH-(1-24) (100mug/day; 14 days) blocks the immobility-reducing "antidepressant" effects of a single dose of imipramine (10mg/kg) in the forced swim test.	Imipramine	138-148	proopiomelanocortin	Homo sapiens	28-32	
23276607-12	2013	Taken together these results indicate that pre-treatment with ACTH (100mug/day; 14 days) blocks the antidepressant effects of imipramine (10mg/kg), significantly alters key PFC monoamine responses to stress and downregulates glucocorticoid responses.	Imipramine	126-136	proopiomelanocortin	Homo sapiens	62-66