PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9845280-0	1998	Imipramine inhibits soluble enkephalin-degrading aminopeptidase activity in vitro.	Imipramine	0-10	proenkephalin	Rattus norvegicus	28-38	
9845280-2	1998	Imipramine in vitro inhibits the enkephalin-degrading aminopeptidase MII and interacts with the enzyme in a mixed competitive-noncompetitive manner.	Imipramine	0-10	proenkephalin	Rattus norvegicus	33-43	
9845280-3	1998	The present work shows that imipramine in vitro also inhibits reversibly soluble enkephalin-degrading aminopeptidase activity in rat brain.	Imipramine	28-38	proenkephalin	Rattus norvegicus	81-91	
9395259-0	1997	Interaction mechanisms of imipramine and desipramine with enkephalin-degrading aminopeptidases in vitro.	Imipramine	26-36	proenkephalin	Rattus norvegicus	58-68	
9395259-3	1997	In this sense, imipramine treatment in vivo increases the enkephalin levels, and this effect is enhanced by inhibitors of enkephalin-degrading enzymes.	Imipramine	15-25	proenkephalin	Rattus norvegicus	58-68	
9395259-3	1997	In this sense, imipramine treatment in vivo increases the enkephalin levels, and this effect is enhanced by inhibitors of enkephalin-degrading enzymes.	Imipramine	15-25	proenkephalin	Rattus norvegicus	122-132	
9395259-4	1997	The present work shows the effects in vitro of imipramine and its active metabolite desipramine on the activities of two membrane-bound enkephalin-degrading aminopeptidases present in rat brain.	Imipramine	47-57	proenkephalin	Rattus norvegicus	136-146	
2885761-3	1987	Imipramine (4 days) resulted in a marked inhibition of the ability of [D-Ala2, D-Leu5] enkephalin to decrease electrically evoked contractions of the vas deferens (presynaptic opioid receptor response) but did not significantly affect the carbachol-induced increase in electrically evoked contractions (muscarinic receptor response).	Imipramine	0-10	proenkephalin	Rattus norvegicus	87-97	
10625117-0	1999	Effect of imipramine on enkephalin-degrading peptidases.	Imipramine	10-20	proenkephalin	Rattus norvegicus	24-34	
10625117-2	1999	In this work, we have measured the effect of imipramine on enkephalin-degrading peptidases in several rat brain areas.	Imipramine	45-55	proenkephalin	Rattus norvegicus	59-69	
10625117-7	1999	These results suggest to us that enkephalin-degrading peptidases are involved in the acute and chronic action mechanism of imipramine and reinforce the idea that the central enkephalinergic activity is dynamically changed during the treatment of depressive illness.	Imipramine	123-133	proenkephalin	Rattus norvegicus	33-43	
9566035-0	1997	Imipramine induces alterations in proenkephalin and prodynorphin mRNAs level in the nucleus accumbens and striatum in the rat.	Imipramine	0-10	proenkephalin	Rattus norvegicus	34-47	
9566035-2	1997	In this study, we evaluated effects of single and repeated imipramine administration on proenkephalin and prodynorphin gene expression in the rat nucleus accumbens and striatum.	Imipramine	59-69	proenkephalin	Rattus norvegicus	88-101