PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19351862-12	2009	Cell proliferation of E6/E7 keratinocytes was decreased by Eag1 antibodies inhibiting channel activity and by the nonspecific Eag1 inhibitors imipramine and astemizole; the latter also increased apoptosis.	Imipramine	142-152	potassium voltage-gated channel subfamily H member 1	Homo sapiens	126-130	
25136578-10	2014	Eag1 inhibitor imipramine or Eag1-shRNA significantly suppressed the proliferation of liposarcoma cells in vitro and in vivo, accompanying with accumulation of cells in the G1 phase.	Imipramine	15-25	potassium voltage-gated channel subfamily H member 1	Homo sapiens	0-4	
15365094-0	2004	Mechanism of block of hEag1 K+ channels by imipramine and astemizole.	Imipramine	43-53	potassium voltage-gated channel subfamily H member 1	Homo sapiens	22-27	
18497958-1	2008	Pharmacological inhibitors of the human ether-a-go-go (hEAG) potassium channel, astemizole and imipramine, have been used to demonstrate that hEAG plays a role in cancer cell proliferation.	Imipramine	95-105	potassium voltage-gated channel subfamily H member 1	Homo sapiens	55-59	
18497958-1	2008	Pharmacological inhibitors of the human ether-a-go-go (hEAG) potassium channel, astemizole and imipramine, have been used to demonstrate that hEAG plays a role in cancer cell proliferation.	Imipramine	95-105	potassium voltage-gated channel subfamily H member 1	Homo sapiens	142-146	
17873312-4	2007	In addition, imipramine was used to identify the involvement of Eag1 in the growth of SGC-7901 and BGC-823 cells.	Imipramine	13-23	potassium voltage-gated channel subfamily H member 1	Homo sapiens	64-68	
16949586-0	2006	Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide.	Imipramine	112-122	potassium voltage-gated channel subfamily H member 1	Homo sapiens	74-79	
16949586-1	2006	The relevance of a point mutation at the C-terminal end of the S6 helix (F468) and the introduction of C-type inactivation in the blockage of hEag1 channels by astemizole, imipramine and dofetilide was tested.	Imipramine	172-182	potassium voltage-gated channel subfamily H member 1	Homo sapiens	142-147	
15365094-2	2004	The tricyclic antidepressant imipramine and the antihistamine astemizole inhibit the current through Eag1 channels and reduce the proliferation of cancer cells.	Imipramine	29-39	potassium voltage-gated channel subfamily H member 1	Homo sapiens	101-105	
15365094-4	2004	Even if both drugs differ in their affinity for hEag1 channels (IC50s are approximately 2 microM for imipramine and approximately 200 nM for astemizole) and in their blocking kinetics, both drugs permeate the membrane and inhibit the hEag1 current by selectively binding to open channels.	Imipramine	101-111	potassium voltage-gated channel subfamily H member 1	Homo sapiens	48-53	
34729805-3	2022	In this study, we investigate the effect of imipramine on Eag1 channel expression in DU145 prostate cancer cells.	Imipramine	44-54	potassium voltage-gated channel subfamily H member 1	Homo sapiens	58-62	
34729805-7	2022	It was observed that all three doses of imipramine significantly reduced Eag1 currents and conductivity compared with the control.	Imipramine	40-50	potassium voltage-gated channel subfamily H member 1	Homo sapiens	73-77	
34729805-9	2022	Similarly, Eag1 channel protein expression was found to be significantly reduced for all three doses of imipramine compared with the control group, but there was no significant difference in gene expression between dose groups.	Imipramine	104-114	potassium voltage-gated channel subfamily H member 1	Homo sapiens	11-15	
34729805-10	2022	Obtained results suggested that imipramine has the potential to be used as a pharmacological agent targeting the Eag1 channel in the treatment of prostate cancer.	Imipramine	32-42	potassium voltage-gated channel subfamily H member 1	Homo sapiens	113-117	
12172639-8	2002	hEAG channels were most sensitive to imipramine (IC50: 3.4 microM at +50 mV), followed by KCa (13.8 microM at +50 mV) and Clvol (12 microM at -100 mV), indicating that hEAG expression may be of importance for proliferation of melanoma cells.	Imipramine	37-47	potassium voltage-gated channel subfamily H member 1	Homo sapiens	0-4	
12172639-8	2002	hEAG channels were most sensitive to imipramine (IC50: 3.4 microM at +50 mV), followed by KCa (13.8 microM at +50 mV) and Clvol (12 microM at -100 mV), indicating that hEAG expression may be of importance for proliferation of melanoma cells.	Imipramine	37-47	potassium voltage-gated channel subfamily H member 1	Homo sapiens	168-172