PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33163980-2 2020 Here we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline, or genetic downregulation of the enzyme prevents infection of cultured cells or freshy isolated human nasal epithelial cells with SARS-CoV-2 or pseudoviral pp-VSV-SARS-CoV-2 particles expressing spike, a bona fide system mimicking SARS-CoV-2 infection. Imipramine 99-109 sphingomyelin phosphodiesterase 1 Homo sapiens 57-78 32975484-4 2020 We find that fluoxetine, a widely used antidepressant and a functional inhibitor of acid sphingomyelinase (FIASMA), efficiently inhibited the entry and propagation of SARS-CoV-2 in the cell culture model without cytotoxic effects and also exerted potent antiviral activity against two currently circulating influenza A virus subtypes, an effect which was also observed upon treatment with the FIASMAs amiodarone and imipramine. Imipramine 416-426 sphingomyelin phosphodiesterase 1 Homo sapiens 84-105 29378782-3 2018 ASM inhibition with imipramine or sphingomyelin phosphodiesterase 1 (SMPD1) siRNA in human lung cells, or by transgenic Smpd1+/- haploinsufficiency of mouse lungs, markedly reduced mTOR- and P70-S6 kinase (Thr 389)-phosphorylation and modified TFEB in a pattern consistent with its activation. Imipramine 20-30 sphingomyelin phosphodiesterase 1 Homo sapiens 0-3 17381401-5 2007 Selected cells were pretreated with the acid sphingomyelinase inhibitor imipramine or CD14 neutralizing antibody. Imipramine 72-82 sphingomyelin phosphodiesterase 1 Homo sapiens 40-61 28238856-7 2017 Additionally, proliferative, but not growth-arrested BAEC, are sensitive to gemcitabine-induced apoptotic death, an effect blocked by inhibiting ASMase with imipramine or by binding ceramide on the cell surface with an anti-ceramide Ab. Imipramine 157-167 sphingomyelin phosphodiesterase 1 Homo sapiens 145-151 26915736-8 2016 Treatment with imipramine, an ASMase inhibitor, inhibited the MF-induced EGFR clustering. Imipramine 15-25 sphingomyelin phosphodiesterase 1 Homo sapiens 30-36 25975536-8 2015 Serine palmitoyltransferase (SPT) inhibition with myriocin prevented melatonin-induced autophagy and ASMase inhibition with imipramine-impaired autophagy flux. Imipramine 124-134 sphingomyelin phosphodiesterase 1 Homo sapiens 101-107 19302792-7 2009 Inhibition of ASM with imipramine completely abrogated MMP-1 induction. Imipramine 23-33 sphingomyelin phosphodiesterase 1 Homo sapiens 14-17 20620184-5 2010 The involvement of ASMase in uptake was confirmed by a pharmacological inhibition of ASMase by imipramine and a subsequent rescue of uptake through external addition of sphingomyelinase, and by using ASMase-deficient cells. Imipramine 95-105 sphingomyelin phosphodiesterase 1 Homo sapiens 19-25 20620184-5 2010 The involvement of ASMase in uptake was confirmed by a pharmacological inhibition of ASMase by imipramine and a subsequent rescue of uptake through external addition of sphingomyelinase, and by using ASMase-deficient cells. Imipramine 95-105 sphingomyelin phosphodiesterase 1 Homo sapiens 85-91 20620184-5 2010 The involvement of ASMase in uptake was confirmed by a pharmacological inhibition of ASMase by imipramine and a subsequent rescue of uptake through external addition of sphingomyelinase, and by using ASMase-deficient cells. Imipramine 95-105 sphingomyelin phosphodiesterase 1 Homo sapiens 85-91 16245071-5 2005 In addition, we demonstrate that the antidepressants imipramine and amitriptyline induce a long-term reduction of the activity of A-SMase in cultured cells. Imipramine 53-63 sphingomyelin phosphodiesterase 1 Homo sapiens 130-137 15705795-4 2005 Desipramine and imipramine, inhibitors of acid sphingomyelinase (ASMase), suppressed RGDfV-induced ceramide increase. Imipramine 16-26 sphingomyelin phosphodiesterase 1 Homo sapiens 42-63 15705795-4 2005 Desipramine and imipramine, inhibitors of acid sphingomyelinase (ASMase), suppressed RGDfV-induced ceramide increase. Imipramine 16-26 sphingomyelin phosphodiesterase 1 Homo sapiens 65-71 10930579-5 2000 Reconstitution of ceramide, the product of acid sphingomyelinase activity, in imipramine- or SR33557-treated cells restores internalization of the bacteria. Imipramine 78-88 sphingomyelin phosphodiesterase 1 Homo sapiens 43-64 35203316-7 2022 Imipramine is mainly used in the treatment of depression and certain anxiety disorders, and it is particularly known as an ASMase inhibitor. Imipramine 0-10 sphingomyelin phosphodiesterase 1 Homo sapiens 123-129 35203316-8 2022 We hypothesized that imipramine could decrease hippocampal neuronal death by reducing ceramide via the inhibition of ASMase after hypoglycemia. Imipramine 21-31 sphingomyelin phosphodiesterase 1 Homo sapiens 117-123 16077898-8 2005 On the other hand, imipramine, an inhibitor of ASM, caused the accumulation of sphingomyelin. Imipramine 19-29 sphingomyelin phosphodiesterase 1 Homo sapiens 47-50 15796901-7 2005 In addition, blockage of ceramide production by ASM inhibitor imipramine interrupted MNNG-induced receptor clustering. Imipramine 62-72 sphingomyelin phosphodiesterase 1 Homo sapiens 48-51 15150117-3 2004 In the present study, we show that the anticancer drug cisplatin induces clustering of CD95 at the surface of the human colon cancer cell line HT29, an event inhibited by the inhibitor of acid sphingomyelinase (aSMase) imipramine. Imipramine 219-229 sphingomyelin phosphodiesterase 1 Homo sapiens 188-209 15150117-3 2004 In the present study, we show that the anticancer drug cisplatin induces clustering of CD95 at the surface of the human colon cancer cell line HT29, an event inhibited by the inhibitor of acid sphingomyelinase (aSMase) imipramine. Imipramine 219-229 sphingomyelin phosphodiesterase 1 Homo sapiens 211-217