PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25719307-2 2015 Thus, CYP2D6 catalyzes the 2-hydroxylation, and CYP2C19 in part catalyzes the N-demethylation of imipramine. Imipramine 97-107 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 6-12 28520379-10 2012 The FDA-approved drug label for imipramine states that CYP2D6 poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants when given usual doses. Imipramine 32-42 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 55-61 27440861-3 2016 Imipramine undergoes N-demethylation to form the active metabolite desipramine, and both imipramine and desipramine are converted to hydroxylated metabolites by the polymorphic enzyme CYP2D6. Imipramine 0-10 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 184-190 27440861-3 2016 Imipramine undergoes N-demethylation to form the active metabolite desipramine, and both imipramine and desipramine are converted to hydroxylated metabolites by the polymorphic enzyme CYP2D6. Imipramine 89-99 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 184-190 27440861-9 2016 Moreover, the PBPK model was able to recover simultaneously plasma profiles of imipramine and desipramine in populations with different phenotypes of CYP2D6. Imipramine 79-89 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 150-156 27632988-7 2017 CONCLUSION: CYP2D6 binding subsite A was found to be relatively selective for small molecular weight with higher polarity compared with subsite B which tends to favor larger molecular weight and relatively hydrophobic molecules such as tamoxifen and imipramine. Imipramine 250-260 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 12-18 16141545-4 2005 The metabolism of clotiazepam was catalyzed by CYP2B6, CYP3A4, CYP2C18, and CYP2C19, and imipramine was metabolized by CYP2D6 most efficiently. Imipramine 89-99 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 119-125 22764579-2 2012 In this study, the co-expression enzyme of human recombinant CYPOR, CYPb5 and CYP2D6.1 or CYP2D6.10 with the Bac-to-Bac system in baculovirus-infected insect cells was used to study the catalytical activity to imipramine metabolism and stereoselective metabolism of propranolol. Imipramine 210-220 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 78-84 22764579-2 2012 In this study, the co-expression enzyme of human recombinant CYPOR, CYPb5 and CYP2D6.1 or CYP2D6.10 with the Bac-to-Bac system in baculovirus-infected insect cells was used to study the catalytical activity to imipramine metabolism and stereoselective metabolism of propranolol. Imipramine 210-220 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 90-96 19884907-1 2010 CYP2C19 converts the tricyclic antidepressant imipramine to its active metabolite desipramine, which is subsequently inactivated by CYP2D6. Imipramine 46-56 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 132-138 17667959-0 2008 Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients. Imipramine 70-80 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 49-55 17667959-1 2008 The inactivation and clearance of the tricyclic antidepressant imipramine is dependent on CYP2D6 activity. Imipramine 63-73 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 90-96 17667959-2 2008 First, CYP2C19 converts imipramine into the active metabolite desipramine, which is then inactivated by CYP2D6. Imipramine 24-34 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 104-110 17667959-3 2008 This retrospective single center study aimed to prove whether CYP2C19 and ample CYP2D6 genotyping (taking into consideration four null alleles and three decreased-activity alleles) could be used to predict imipramine and desipramine plasma concentrations in depressed patients, and whether genotype-based drug dose recommendations might assist in the early management of imipramine pharmacotherapy. Imipramine 206-216 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 80-86 17667959-5 2008 Desipramine and imipramine+desipramine plasma concentration per drug dose unit, imipramine dose at steady state, and imipramine dose requirement significantly depended on CYP2D6 genotype (Kruskal-Wallis test, P<0.0001). Imipramine 16-26 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 171-177 17667959-5 2008 Desipramine and imipramine+desipramine plasma concentration per drug dose unit, imipramine dose at steady state, and imipramine dose requirement significantly depended on CYP2D6 genotype (Kruskal-Wallis test, P<0.0001). Imipramine 80-90 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 171-177 17667959-5 2008 Desipramine and imipramine+desipramine plasma concentration per drug dose unit, imipramine dose at steady state, and imipramine dose requirement significantly depended on CYP2D6 genotype (Kruskal-Wallis test, P<0.0001). Imipramine 80-90 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 171-177 17667959-8 2008 Our protocol for CYP2D6 genotyping will thus importantly aid in the prediction of imipramine metabolism, allowing for the use of an adjusted starting dose and faster achievement of predefined imipramine+desipramine plasma levels in all genetic patient subgroups. Imipramine 82-92 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 17-23 17667959-8 2008 Our protocol for CYP2D6 genotyping will thus importantly aid in the prediction of imipramine metabolism, allowing for the use of an adjusted starting dose and faster achievement of predefined imipramine+desipramine plasma levels in all genetic patient subgroups. Imipramine 192-202 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 17-23 18310890-5 2008 Imipramine, desipramine, mazindol, and GBR12909 competitively inhibited PROG 21-hydroxylation mediated by CYP2D4 and/or CYP2D6, and all psychotropic drugs inhibited ALLO 21-hydroxylation mediated by CYP2D4 and/or CYP2D6. Imipramine 0-10 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 120-126 18310890-5 2008 Imipramine, desipramine, mazindol, and GBR12909 competitively inhibited PROG 21-hydroxylation mediated by CYP2D4 and/or CYP2D6, and all psychotropic drugs inhibited ALLO 21-hydroxylation mediated by CYP2D4 and/or CYP2D6. Imipramine 0-10 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 213-219 18310890-6 2008 The inhibition constants (Ki values) of imipramine, desipramine, and mazindol against the 21-hydroxylation of PROG and ALLO by CYP2D6 were lower than those by CYP2D4. Imipramine 40-50 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 127-133 16141545-6 2005 These results suggest that the psychotropic drugs investigated are metabolized predominantly by CYP3A4, except that CYP2D6 catalyzes the metabolism of imipramine. Imipramine 151-161 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 116-122 12065442-5 2002 KM values spanned an 80-fold range from 0.12 microM (CYP2D6-catalyzed thioridazine S-oxidation) to 9.8 microM (CYP2C19-catalyzed imipramine N-demethylation). Imipramine 129-139 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 53-59 15687478-10 2005 Fluoxetine is a potent inhibitor of CYP2D6, and imipramine is metabolized by CYP2D6. Imipramine 48-58 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 77-83 12695349-1 2003 The effects of microsomal concentration on the inhibitory potencies of four compounds--fluoxetine, quinidine, imipramine, and ezlopitant--on heterologously expressed recombinant CYP2D6-catalyzed bufuralol 1"-hydroxylase activity were determined. Imipramine 110-120 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 178-184 9512923-2 1997 Imipramine possesses such characteristics and is both a substrate and an inhibitor of the CYP2D6 enzyme. Imipramine 0-10 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 90-96 9505989-3 1997 Imipramine pharmacokinetics serve as a marker for hepatic CYP2D6, CYP1A2, CYP3A activity. Imipramine 0-10 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 58-64 9512923-4 1997 Imipramine inhibited the 1"-hydroxylation of bufuralol (10 microM), an in vitro marker of CYP2D6 activity, in a CYP2D6 cell line (IC50 = 2.4 microM). Imipramine 0-10 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 90-96 9512923-4 1997 Imipramine inhibited the 1"-hydroxylation of bufuralol (10 microM), an in vitro marker of CYP2D6 activity, in a CYP2D6 cell line (IC50 = 2.4 microM). Imipramine 0-10 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 112-118 9205822-0 1997 Venlafaxine: in vitro inhibition of CYP2D6 dependent imipramine and desipramine metabolism; comparative studies with selected SSRIs, and effects on human hepatic CYP3A4, CYP2C9 and CYP1A2. Imipramine 53-63 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 36-42 9256169-6 1997 The binding of [3H]GBR-12935 to CYP2D6 was decreased partially by substrates or inhibitors of CYP2D isoforms (quinine, quinidine, propranolol, bufuralol, imipramine, and desipramine). Imipramine 154-164 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 32-38 9256169-6 1997 The binding of [3H]GBR-12935 to CYP2D6 was decreased partially by substrates or inhibitors of CYP2D isoforms (quinine, quinidine, propranolol, bufuralol, imipramine, and desipramine). Imipramine 154-164 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 32-37 9205822-1 1997 AIMS: In order to anticipate drug-interactions of potential clinical significance the ability of the novel antidepressant, venlafaxine, to inhibit CYP2D6 dependent imipramine and desipramine 2-hydroxylation was investigated in human liver microsomes. Imipramine 164-174 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 147-153 9205822-5 1997 The inhibitory effect of imipramine and desipramine on liver microsomal CYP2D6 dependent venlafaxine O-demethylation was determined similarly. Imipramine 25-35 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 72-78 9205822-10 1997 Imipramine and desipramine gave marked inhibition of CYP2D6 dependent venlafaxine O-demethylase activity (Ki values of 3.9 +/- 1.7 and 1.7 +/- 0.9 microM, respectively). Imipramine 0-10 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 53-59 8335704-0 1993 Metabolism of imipramine in vitro by isozyme CYP2D6 expressed in a human cell line, and observations on metabolite stability. Imipramine 14-24 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 45-51 8835703-5 1996 This index correlated with the 4"-hydroxylation of S-mephenytoin (rs = -0.51, p < 0.01), but not with the alpha-hydroxylation of metoprolol, implying that imipramine N-demethylation is under a coregulatory pharmacogenetic control of CYP2C19, but not of CYP2D6. Imipramine 158-168 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 256-262 8521680-9 1995 While CYP2D6 catalyses the metabolism of lipophilic bases only, CYP2C19 is involved in the metabolism of acids (e.g. S-mephenytoin), bases (e.g. imipramine and omeprazole) and neutral drugs (e.g. diazepam). Imipramine 145-155 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 6-12 8310712-0 1993 Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line. Imipramine 12-22 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 65-71 8310712-2 1993 A commercially-available human cytochrome P450 isozyme (CYP2D6) preparation was used in imipramine metabolism studies. Imipramine 88-98 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 56-62 8310712-14 1993 CYP2D6 catalyses C-hydroxylation of imipramine to 2-hydroxyimipramine more efficiently than its N-demethylation to desipramine. Imipramine 36-46 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 0-6 8335704-1 1993 A metabolism study of imipramine (IMI) has been conducted in vitro with commercially available human CYP2D6 isozyme expressed in a human AHH-1 TK +/- cell line. Imipramine 22-32 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 101-107 8335704-1 1993 A metabolism study of imipramine (IMI) has been conducted in vitro with commercially available human CYP2D6 isozyme expressed in a human AHH-1 TK +/- cell line. Imipramine 34-37 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 101-107