PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31420165-0	2019	Rapid antidepressant actions of imipramine potentiated by zinc through PKA-dependented regulation of mTOR and CREB signaling.	Imipramine	32-42	cAMP responsive element binding protein 1	Homo sapiens	110-114	
31420165-8	2019	Combination of zinc with imipramine rapidly enhanced the phosphorylation of mTOR Ser2448 and CREB Ser133, and increased the expression of mTOR and CREB, which were dependent on the activation of PKA.	Imipramine	25-35	cAMP responsive element binding protein 1	Homo sapiens	93-97	
31420165-8	2019	Combination of zinc with imipramine rapidly enhanced the phosphorylation of mTOR Ser2448 and CREB Ser133, and increased the expression of mTOR and CREB, which were dependent on the activation of PKA.	Imipramine	25-35	cAMP responsive element binding protein 1	Homo sapiens	147-151	
28462695-2	2017	AMPA receptor and cAMP response element-binding protein (CREB) are involved in the antidepressant actions of Ketamine and imipramine, a traditional tricyclic antidepressant.	Imipramine	122-132	cAMP responsive element binding protein 1	Homo sapiens	18-55	
28462695-5	2017	RESULTS: Here we show that the enhancement of the phosphorylation of CREB Ser133 and expression of CREB and glutamate receptor 1 (GluR1) are necessary for both ketamine"s and imipramine"s antidepressant actions, but the enhancements at early stage may account for the faster onset of ketamine"s antidepressant action than imipramine.	Imipramine	322-332	cAMP responsive element binding protein 1	Homo sapiens	69-73	
28462695-5	2017	RESULTS: Here we show that the enhancement of the phosphorylation of CREB Ser133 and expression of CREB and glutamate receptor 1 (GluR1) are necessary for both ketamine"s and imipramine"s antidepressant actions, but the enhancements at early stage may account for the faster onset of ketamine"s antidepressant action than imipramine.	Imipramine	322-332	cAMP responsive element binding protein 1	Homo sapiens	99-103	
28462695-2	2017	AMPA receptor and cAMP response element-binding protein (CREB) are involved in the antidepressant actions of Ketamine and imipramine, a traditional tricyclic antidepressant.	Imipramine	122-132	cAMP responsive element binding protein 1	Homo sapiens	57-61	
28462695-5	2017	RESULTS: Here we show that the enhancement of the phosphorylation of CREB Ser133 and expression of CREB and glutamate receptor 1 (GluR1) are necessary for both ketamine"s and imipramine"s antidepressant actions, but the enhancements at early stage may account for the faster onset of ketamine"s antidepressant action than imipramine.	Imipramine	175-185	cAMP responsive element binding protein 1	Homo sapiens	69-73	
28462695-5	2017	RESULTS: Here we show that the enhancement of the phosphorylation of CREB Ser133 and expression of CREB and glutamate receptor 1 (GluR1) are necessary for both ketamine"s and imipramine"s antidepressant actions, but the enhancements at early stage may account for the faster onset of ketamine"s antidepressant action than imipramine.	Imipramine	175-185	cAMP responsive element binding protein 1	Homo sapiens	99-103	
12482470-0	2003	Differential effects of fluoxetine and imipramine on the phosphorylation of the transcription factor CREB and cell-viability.	Imipramine	39-49	cAMP responsive element binding protein 1	Homo sapiens	101-105	
12482470-3	2003	In the present study we evaluated if the antidepressants imipramine and fluoxetine are capable to influence the translational expression and phosphorylation of CREB (pCREB) in cells known to be apoptosis-inducible by antidepressants.	Imipramine	57-67	cAMP responsive element binding protein 1	Homo sapiens	160-164	
12482470-8	2003	Treating cells with lowest concentrations only imipramine revealed an increase of CREB-phosphorylation after long-time treatment over 3 weeks.	Imipramine	47-57	cAMP responsive element binding protein 1	Homo sapiens	82-86	
26433268-8	2015	Accordingly, stress and imipramine induced opposite changes on AcH3, AcH4 and CREB expression.	Imipramine	24-34	cAMP responsive element binding protein 1	Homo sapiens	78-82