PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23931269-1	2013	The pharmacological concept that inhibition of the drug efflux pump P-glycoprotein (P-gp) enhances brain distribution of the antidepressant imipramine in the rat has recently been demonstrated.	Imipramine	140-150	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	68-82	
23931269-1	2013	The pharmacological concept that inhibition of the drug efflux pump P-glycoprotein (P-gp) enhances brain distribution of the antidepressant imipramine in the rat has recently been demonstrated.	Imipramine	140-150	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	84-88	
22250926-0	2012	Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats.	Imipramine	51-61	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	14-28	
22250926-3	2012	Therefore, the present study aimed to investigate the effect of P-gp inhibition on the transport of the tricyclic antidepressant imipramine and its active metabolite desipramine across the BBB.	Imipramine	129-139	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	64-68	
22250926-9	2012	CONCLUSIONS AND IMPLICATIONS: The present study demonstrated that P-gp inhibition enhanced the intracerebral concentration of imipramine , thus supporting the hypothesis that P-gp activity restricts brain levels of certain antidepressants, including imipramine.	Imipramine	126-136	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	66-70	
22250926-9	2012	CONCLUSIONS AND IMPLICATIONS: The present study demonstrated that P-gp inhibition enhanced the intracerebral concentration of imipramine , thus supporting the hypothesis that P-gp activity restricts brain levels of certain antidepressants, including imipramine.	Imipramine	126-136	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	175-179	
22250926-9	2012	CONCLUSIONS AND IMPLICATIONS: The present study demonstrated that P-gp inhibition enhanced the intracerebral concentration of imipramine , thus supporting the hypothesis that P-gp activity restricts brain levels of certain antidepressants, including imipramine.	Imipramine	250-260	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	66-70	
22250926-9	2012	CONCLUSIONS AND IMPLICATIONS: The present study demonstrated that P-gp inhibition enhanced the intracerebral concentration of imipramine , thus supporting the hypothesis that P-gp activity restricts brain levels of certain antidepressants, including imipramine.	Imipramine	250-260	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	175-179