PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26915317-13 2016 The underlying mechanisms of imipramine"s anti-depressive effect may be associated with the down-regulation of betaCaMKII and membrane GluR1 in the habenula, as well as the up-regulation of membrane GluR1 in the prefrontal cortex. Imipramine 29-39 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 135-140 18634600-7 2004 By contrast,imipramine, which can provoke mania, increases synaptic expression of GluR1 in the hippocampus in vivo. Imipramine 12-22 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 82-87 15269270-9 2004 In contrast, imipramine, an antidepressant that can trigger manic episodes, increased synaptic expression of GluR1 in hippocampus in vivo. Imipramine 13-23 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 109-114 26915317-13 2016 The underlying mechanisms of imipramine"s anti-depressive effect may be associated with the down-regulation of betaCaMKII and membrane GluR1 in the habenula, as well as the up-regulation of membrane GluR1 in the prefrontal cortex. Imipramine 29-39 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 199-204