PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27364961-14 2016 Imipramine treatment reversed depressive-like behaviors, re-established hippocampal BDNF and GDNF expression, and normalized ACTH levels in the blood. Imipramine 0-10 brain-derived neurotrophic factor Rattus norvegicus 84-88 22423384-9 2012 Diabetic rats injected with saline did not show altered BDNF levels in the prefrontal cortex, hippocampus or amygdala, but interestingly, the treatment with imipramine in diabetic animals increased BDNF levels in the prefrontal cortex. Imipramine 157-167 brain-derived neurotrophic factor Rattus norvegicus 56-60 22423384-9 2012 Diabetic rats injected with saline did not show altered BDNF levels in the prefrontal cortex, hippocampus or amygdala, but interestingly, the treatment with imipramine in diabetic animals increased BDNF levels in the prefrontal cortex. Imipramine 157-167 brain-derived neurotrophic factor Rattus norvegicus 198-202 29151391-10 2018 Moreover, in an independent experimental group, only repeated treatment with 7-NI and imipramine increased BDNF protein levels in the hippocampus. Imipramine 86-96 brain-derived neurotrophic factor Rattus norvegicus 107-111 35597327-0 2022 Pro-cognitive effect of acute imipramine administration correlates with direct interaction of BDNF with its receptor, Trkbeta. Imipramine 30-40 brain-derived neurotrophic factor Rattus norvegicus 94-98 25156823-0 2014 Imipramine ameliorates pain-related negative emotion via induction of brain-derived neurotrophic factor. Imipramine 0-10 brain-derived neurotrophic factor Rattus norvegicus 70-103 25840741-4 2015 The results showed that short- (3 days) or long-term (21 days) systemic treatment with the tricyclic ADs imipramine, clomipramine or desipramine increased BDNF levels in the DPAG. Imipramine 105-115 brain-derived neurotrophic factor Rattus norvegicus 155-159 26730329-11 2015 Imipramine and crocin prevented the decreasing effect of malathion on BDNF. Imipramine 0-10 brain-derived neurotrophic factor Rattus norvegicus 70-74 25739024-8 2015 Chronic imipramine reversed the lesion-induced decreases in BDNF mRNA in the DG. Imipramine 8-18 brain-derived neurotrophic factor Rattus norvegicus 60-64 23238043-0 2013 Imipramine reverses alterations in cytokines and BDNF levels induced by maternal deprivation in adult rats. Imipramine 0-10 brain-derived neurotrophic factor Rattus norvegicus 49-53 23238043-11 2013 Interestingly, imipramine treatment reversed the effects of maternal deprivation on BDNF and cytokines levels (p<0.05). Imipramine 15-25 brain-derived neurotrophic factor Rattus norvegicus 84-88 22310305-9 2013 Finally, chronic administration of imipramine significantly increased mBDNF levels, but not pro-BDNF and protease levels, indicating that the therapeutic mechanism of imipramine differs from that of ECS. Imipramine 35-45 brain-derived neurotrophic factor Rattus norvegicus 71-75 22529824-3 2012 RESULTS: Stimulation of astroglial cell culture with imipramine, a tricyclic antidepressant, led to a significant increase of the Bdnf RNA level whereas treatment with escitalopram did not. Imipramine 53-63 brain-derived neurotrophic factor Rattus norvegicus 130-134 23076128-0 2012 Imipramine induces brain-derived neurotrophic factor mRNA expression in cultured astrocytes. Imipramine 0-10 brain-derived neurotrophic factor Rattus norvegicus 19-52 23076128-4 2012 In the present study, we evaluated the effects of imipramine, a classic tricyclic antidepressant drug, on BDNF expression in cultured rat brain astrocytes. Imipramine 50-60 brain-derived neurotrophic factor Rattus norvegicus 106-110 23076128-5 2012 Imipramine dose-dependently increased BDNF mRNA expression in astrocytes. Imipramine 0-10 brain-derived neurotrophic factor Rattus norvegicus 38-42 23076128-6 2012 The imipramine-induced BDNF increase was suppressed with inhibitors for protein kinase A (PKA) or MEK/ERK. Imipramine 4-14 brain-derived neurotrophic factor Rattus norvegicus 23-27 23076128-8 2012 These results suggested that imipramine induced BDNF expression through CREB activation via PKA and/or ERK pathways. Imipramine 29-39 brain-derived neurotrophic factor Rattus norvegicus 48-52 23076128-9 2012 Imipramine treatment in depression might exert antidepressant action through BDNF production from astrocytes, and glial BDNF expression might be a target of developing novel antidepressants. Imipramine 0-10 brain-derived neurotrophic factor Rattus norvegicus 77-81 25379896-0 2011 Administration of cannabidiol and imipramine induces antidepressant-like effects in the forced swimming test and increases brain-derived neurotrophic factor levels in the rat amygdala. Imipramine 34-44 brain-derived neurotrophic factor Rattus norvegicus 123-156 21930150-13 2011 The results support a role for central BDNF in depressogenic effects of alcohol and antidepressant effects of nomifensine and imipramine. Imipramine 126-136 brain-derived neurotrophic factor Rattus norvegicus 39-43 21397634-7 2011 Combined treatment with ketamine and imipramine produced stronger increases of CREB and BDNF protein levels in the prefrontal cortex, hippocampus and amygdala, and PKA phosphorylation in the hippocampus and amygdala and PKC phosphorylation in prefrontal cortex. Imipramine 37-47 brain-derived neurotrophic factor Rattus norvegicus 88-92 21397634-0 2011 Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain. Imipramine 14-24 brain-derived neurotrophic factor Rattus norvegicus 95-99 19954760-5 2010 Brain-derived neurotrophic factor (BDNF) hippocampal levels were assessed in imipramine- and memantine-treated rats by ELISA sandwich assay. Imipramine 77-87 brain-derived neurotrophic factor Rattus norvegicus 0-33 21602609-2 2011 The present study investigates the effect of chronic (16 days) combined treatment with zinc (15 mg/kg zinc hydroaspartate) and imipramine (5 mg/kg) in chronic unpredictable stress (CUS) on the BDNF mRNA level in the rat brain. Imipramine 127-137 brain-derived neurotrophic factor Rattus norvegicus 193-197 21602609-7 2011 However, combined treatment of zinc and imipramine induced a 12% elevation of the BDNF mRNA level in the stressed but not in the unstressed rats. Imipramine 40-50 brain-derived neurotrophic factor Rattus norvegicus 82-86 17950272-2 2008 This study was undertaken to investigate the time-course of the effect of three antidepressants; fluoxetine, imipramine and venlafaxine, which differentially affect monoamine reuptake, on BDNF mRNA expression in the hippocampus. Imipramine 109-119 brain-derived neurotrophic factor Rattus norvegicus 188-192 18657555-9 2009 Altogether, these results indicate that acute elevated platform stress down-regulates a putative BDNF/MEK/MAPK signaling cascade in the frontal cortex in a manner that is reversible by the antidepressants tianeptine and imipramine. Imipramine 220-230 brain-derived neurotrophic factor Rattus norvegicus 97-101 17566715-0 2008 Neuroprotection by Imipramine against lipopolysaccharide-induced apoptosis in hippocampus-derived neural stem cells mediated by activation of BDNF and the MAPK pathway. Imipramine 19-29 brain-derived neurotrophic factor Rattus norvegicus 142-146 19632287-3 2009 The present study aims to compare the behavioral effects and the BDNF hippocampus levels of acute administration of harmine and imipramine in rats. Imipramine 128-138 brain-derived neurotrophic factor Rattus norvegicus 65-69 19632287-5 2009 Afterwards, hippocampal BDNF protein levels were assessed in imipramine- and harmine-treated rats by ELISA-sandwich assay. Imipramine 61-71 brain-derived neurotrophic factor Rattus norvegicus 24-28 17950272-6 2008 BDNF mRNA levels in the dentate gyrus (DG) were increased after treatment with venlafaxine (7, 14 and 21 days) and imipramine (14 and 21 days), but not after treatment with fluoxetine, indicating that stimulation of BDNF mRNA expression is dependent on the pharmacological profile and on the time-course of drug treatment. Imipramine 115-125 brain-derived neurotrophic factor Rattus norvegicus 0-4 17950272-9 2008 These results suggest that venlafaxine and imipramine, but not fluoxetine, induce neuroplastic effects in the hippocampus through stimulation of BDNF mRNA expression, and that the effect on BDNF is not directly translated into regulation of synaptophysin and GAP-43 mRNA. Imipramine 43-53 brain-derived neurotrophic factor Rattus norvegicus 145-149 17950272-9 2008 These results suggest that venlafaxine and imipramine, but not fluoxetine, induce neuroplastic effects in the hippocampus through stimulation of BDNF mRNA expression, and that the effect on BDNF is not directly translated into regulation of synaptophysin and GAP-43 mRNA. Imipramine 43-53 brain-derived neurotrophic factor Rattus norvegicus 190-194 17884272-3 2008 Considering that classic antidepressants may take long-lasting time to exhibit their main therapeutic effects, the present study aims to compare the behavioral effects and the BDNF hippocampus levels of acute administration of ketamine and imipramine in rats. Imipramine 240-250 brain-derived neurotrophic factor Rattus norvegicus 176-180 17884272-5 2008 Afterwards, BDNF protein hippocampal levels were assessed in imipramine- and ketamine-treated rats by ELISA-sandwich assay. Imipramine 61-71 brain-derived neurotrophic factor Rattus norvegicus 12-16 15363987-10 2004 The reduction of CRE-binding activities and BDNF levels in the frontal cortex or hippocampus in learned helplessness rats were ameliorated by treatment with imipramine or rolipram alone. Imipramine 157-167 brain-derived neurotrophic factor Rattus norvegicus 44-48 17622693-0 2007 Repeated co-treatment with imipramine and amantadine induces hippocampal brain-derived neurotrophic factor gene expression in rats. Imipramine 27-37 brain-derived neurotrophic factor Rattus norvegicus 73-106 17622693-10 2007 Joint administration of IMI (5 or 10 mg/kg) and AMA (10 mg/kg) induced a more potent increase BDNF gene expression in the hippocampus (but not in cerebral cortex) and either inhibited the behavioral syndrome induced by (+/-)DOI or did not change the action of 8-OH-DPAT (compared to treatment with either drug alone). Imipramine 24-27 brain-derived neurotrophic factor Rattus norvegicus 94-98 16956981-7 2006 Conversely, although imipramine did not provide significant behavioral analgesia, it significantly blocked both pain- and stress-evoked alterations in hippocampal and spinal NK-1 and BDNF gene expression. Imipramine 21-31 brain-derived neurotrophic factor Rattus norvegicus 183-187 16382205-0 2005 Combined treatment with imipramine and metyrapone induces hippocampal and cortical brain-derived neurotrophic factor gene expression in rats. Imipramine 24-34 brain-derived neurotrophic factor Rattus norvegicus 83-116 16382205-9 2005 Joint administration of IMI (10 mg/kg) and MET (50 mg/kg) induced a more potent increase BDNF gene expression in both the examined brain regions (compared to the treatment with either drug alone). Imipramine 24-27 brain-derived neurotrophic factor Rattus norvegicus 89-93 15363987-11 2004 CRE-binding activities and/or BDNF levels of the frontal cortex and hippocampus were significantly increased by treatment with a combination of rolipram and imipramine compared to those in imipramine-treated rats. Imipramine 157-167 brain-derived neurotrophic factor Rattus norvegicus 30-34 12742641-0 2003 Effects of chronic exercise and imipramine on mRNA for BDNF after olfactory bulbectomy in rat. Imipramine 32-42 brain-derived neurotrophic factor Rattus norvegicus 55-59