PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9868741-1	1998	The selective serotonin re-uptake inhibitor, fluvoxamine, is a very potent inhibitor of CYP1A2, and accordingly causes pharmacokinetic interactions with drugs metabolised by CYP1A2, such as caffeine, theophylline, imipramine, tacrine and clozapine.	Imipramine	214-224	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	88-94	
19904008-8	2009	Hence, taking account of CYP1A2 contribution to the metabolism of endogenous substances (steroids), drugs (xanthine derivatives, phenacetin, propranolol, imipramine, phenothiazine neuroleptics, clozapine) and carcinogenic compounds, the inhibition of CYP1A2 by perazine may be of physiological, pharmacological and toxicological importance.	Imipramine	154-164	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	25-31	
15199661-1	2004	Tricyclic antidepressants are all hydroxylated by cytochrome P450 (CYP) 2D6, but the tertiary amines, amitriptyline, clomipramine and imipramine, are also N-demethylated to the active metabolites, nortriptyline, N-desmethylclomipramine and desipramine, by several CYPs, including the polymorphic CYP2C19, CYP1A2 and CYP3A4.	Imipramine	134-144	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	305-311	
11714871-7	2001	The inactivation of liver microsomal CYP1A2 by trans-resveratrol required NADPH, was not reversible by dialysis, and was not affected by the trapping agents glutathione, N-acetylcysteine, catalase, or superoxide dismutase, but was attenuated by a CYP1A2 substrate, imipramine.	Imipramine	265-275	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-43	
9868741-1	1998	The selective serotonin re-uptake inhibitor, fluvoxamine, is a very potent inhibitor of CYP1A2, and accordingly causes pharmacokinetic interactions with drugs metabolised by CYP1A2, such as caffeine, theophylline, imipramine, tacrine and clozapine.	Imipramine	214-224	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	174-180	
9490065-7	1998	In liver microsomes, the demethylation of imipramine was essentially due to CYP1A2 and to a smaller extent to CYP3A.	Imipramine	42-52	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	76-82	
9505989-3	1997	Imipramine pharmacokinetics serve as a marker for hepatic CYP2D6, CYP1A2, CYP3A activity.	Imipramine	0-10	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	66-72	
9351907-6	1997	Other substrates of CYP1A2, such as phenacetin, imipramine, caffeine, and estradiol, are also inhibitors of flutamide metabolism by CYP1A2.	Imipramine	48-58	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26	
9351907-6	1997	Other substrates of CYP1A2, such as phenacetin, imipramine, caffeine, and estradiol, are also inhibitors of flutamide metabolism by CYP1A2.	Imipramine	48-58	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	132-138	
9324197-6	1997	Imipramine is metabolized in the liver by the cytochrome P-450 (CYP 1A2) system, and barbiturates are known inducers of this enzyme subset.	Imipramine	0-10	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	46-71	
9084457-2	1997	At least three different P450s appear to be responsible for the N-demethylation of imipramine to desipramine in vivo: CYP1A2, CYP2C19, and CYP3A4.	Imipramine	83-93	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	118-124	
9084457-0	1997	Imipramine demethylation in vivo: impact of CYP1A2, CYP2C19, and CYP3A4.	Imipramine	0-10	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	44-50	
7640151-11	1995	This indicates that CYP1A2, which is induced by cigarette smoking, also catalyzes the N-demethylation of imipramine.	Imipramine	105-115	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	20-26	
8846618-11	1995	Consistent with its minimal in vitro effect on CYP2D6, fluvoxamine shows minimal in vivo pharmacokinetic interaction with desipramine, but does interact with imipramine (approximately 3- to 4-fold increase in AUC) through inhibition of CYP3A3/4, CYP1A2, and CYP2C19.	Imipramine	158-168	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	246-252	
8846619-2	1995	Cytochrome P450 1A2 (CYP1A2) accounts for about 10 to 15% of the total CYP content of human liver and is the major enzyme involved in the metabolism of imipramine, propranolol, clozapine, theophylline, and caffeine.	Imipramine	152-162	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	0-19	
8846619-2	1995	Cytochrome P450 1A2 (CYP1A2) accounts for about 10 to 15% of the total CYP content of human liver and is the major enzyme involved in the metabolism of imipramine, propranolol, clozapine, theophylline, and caffeine.	Imipramine	152-162	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	21-27	
8466541-5	1993	Our findings explain the mechanism of the pharmacokinetic interactions between fluvoxamine and drugs that are metabolized by CYP1A2, e.g. theophylline and imipramine.	Imipramine	155-165	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	125-131