PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1671867-9	1991	In the light of data that major depression is associated with an activation of brain CRH and LC-NE systems, the time-dependent effect of long-term imipramine administration on decreasing the gene expression of CRH in the hypothalamus and TH in the LC may be relevant to the therapeutic efficacy of this agent in depression.	Imipramine	147-157	corticotropin releasing hormone	Rattus norvegicus	85-88	
7847180-1	1994	Imipramine was administered chronically to LEW/N, outbred and F344/N rats which were then exposed to the aseptic irritant carrageenin in order to determine whether the decreased hypothalamic expression of CRH m-RNA previously shown to be associated with imipramine affects peripheral immune processes.	Imipramine	0-10	corticotropin releasing hormone	Rattus norvegicus	205-208	
11526469-11	2001	The stress-induced increases in mRNA levels of CRH in the PVN and TH in the locus coeruleus were reduced by imipramine but not by Hypericum.	Imipramine	108-118	corticotropin releasing hormone	Rattus norvegicus	47-50	
7675318-0	1995	Chronic imipramine, L-sulpiride and mianserin decrease corticotropin releasing factor levels in the rat brain.	Imipramine	8-18	corticotropin releasing hormone	Rattus norvegicus	55-85	
1671867-9	1991	In the light of data that major depression is associated with an activation of brain CRH and LC-NE systems, the time-dependent effect of long-term imipramine administration on decreasing the gene expression of CRH in the hypothalamus and TH in the LC may be relevant to the therapeutic efficacy of this agent in depression.	Imipramine	147-157	corticotropin releasing hormone	Rattus norvegicus	210-213	
2553044-1	1989	We examined the effects of chronic treatment with antidepressants (imipramine or desipramine) or benzodiazepines (diazepam, alprazolam, or adinazolam) on modulation of corticotropin-releasing-factor (CRF) receptors in discrete areas of rat brain and in anterior pituitary.	Imipramine	67-77	corticotropin releasing hormone	Rattus norvegicus	168-198