PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21368751-3 2011 We have shown in vitro that ezetimibe and tacrolimus may interact in competition for intestinal UGT1A1 and ABCB1 at concentrations reached in gut lumen after oral administration. Ezetimibe 28-37 ATP binding cassette subfamily B member 1 Homo sapiens 107-112 20220747-1 2010 Organ transplant recipients who have dyslipidemia related to immunosuppression may benefit from cholesterol-lowering therapy with ezetimibe, a substrate of ABCB1, ABCC2, and OATP1B1. Ezetimibe 130-139 ATP binding cassette subfamily B member 1 Homo sapiens 156-161 20220747-3 2010 However, competition between sirolimus and ezetimibe for ABCB1 and OATP1B1 is not of major clinical relevance, as confirmed in our randomized, controlled, single-dose study in healthy subjects. Ezetimibe 43-52 ATP binding cassette subfamily B member 1 Homo sapiens 57-62 17828742-1 2007 The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. Ezetimibe 25-34 ATP binding cassette subfamily B member 1 Homo sapiens 142-156 17828742-1 2007 The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. Ezetimibe 25-34 ATP binding cassette subfamily B member 1 Homo sapiens 158-162 17828742-1 2007 The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. Ezetimibe 36-38 ATP binding cassette subfamily B member 1 Homo sapiens 142-156 17828742-1 2007 The lipid lowering agent ezetimibe (EZ) and its intestinally formed glucuronide (GLUC) were shown to be substrates of the efflux transporters P-glycoprotein (P-gp) and the multidrug resistance associated protein 2 (MRP2) which markedly influences the disposition and efficacy of EZ in man. Ezetimibe 36-38 ATP binding cassette subfamily B member 1 Homo sapiens 158-162 16513445-0 2006 Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetimibe in humans. Ezetimibe 243-252 ATP binding cassette subfamily B member 1 Homo sapiens 25-39 16513445-8 2006 Intestinal expression of UGT1A1, ABCB1, and ABCC2 was inversely correlated with the effects of ezetimibe on plant sterol serum concentrations. Ezetimibe 95-104 ATP binding cassette subfamily B member 1 Homo sapiens 33-38 16513445-0 2006 Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetimibe in humans. Ezetimibe 243-252 ATP binding cassette subfamily B member 1 Homo sapiens 41-46 16513445-9 2006 Parallel in vitro studies confirmed that ezetimibe glucuronide is a high-affinity substrate of MRP2 and has a low affinity to P-gp whereas ezetimibe interacts with P-gp and MRP2. Ezetimibe 41-50 ATP binding cassette subfamily B member 1 Homo sapiens 126-130 16513445-6 2006 The affinity of ezetimibe and its glucuronide to P-gp and MRP2 was assessed in P-gp- overexpressing Madin-Darby canine kidney II cells and P-gp-containing or MRP2-containing inside-out vesicles. Ezetimibe 16-25 ATP binding cassette subfamily B member 1 Homo sapiens 79-83 16513445-10 2006 CONCLUSIONS: The disposition and sterol-lowering effects of ezetimibe are modified by metabolic degradation of the drug via intestinal UGT1A1 and either intestinal or hepatic secretion (or both) via P-gp and MRP2. Ezetimibe 60-69 ATP binding cassette subfamily B member 1 Homo sapiens 199-203 16513445-6 2006 The affinity of ezetimibe and its glucuronide to P-gp and MRP2 was assessed in P-gp- overexpressing Madin-Darby canine kidney II cells and P-gp-containing or MRP2-containing inside-out vesicles. Ezetimibe 16-25 ATP binding cassette subfamily B member 1 Homo sapiens 79-83