PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31188588-2 2019 We report here two GALNS pharmacological chaperones, ezetimibe and pranlukast, identified by molecular docking-based virtual screening. Ezetimibe 53-62 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 19-24 31188588-6 2019 Combined treatment of recombinant GALNS with ezetimibe or pranlukast produced an additive effect. Ezetimibe 45-54 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 34-39 31188588-7 2019 Altogether, the results demonstrate that ezetimibe and pranlukast can increase the yield of recombinant GALNS and be used as a monotherapy or combination therapy to improve the therapeutic efficacy of MPS IVA enzyme replacement therapy. Ezetimibe 41-50 galactosamine (N-acetyl)-6-sulfatase Homo sapiens 104-109