PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32743640-0 2021 Irinotecan and vandetanib create synergies for treatment of pancreatic cancer patients with concomitant TP53 and KRAS mutations. vandetanib 15-25 tumor protein p53 Homo sapiens 104-108 32743640-8 2021 Irinotecan and vandetanib are prospective drugs for PAAD patients with KRASG12Dmutation and TP53 mutation. vandetanib 15-25 tumor protein p53 Homo sapiens 92-96 28159923-2 2017 SHH-TP53-mutated as well as MYC-amplified Non-WNT/Non-SHH medulloblastoma show the worst prognosis.Here we present evidence that single application of the multi-kinase inhibitor Vandetanib displays anti-neoplastic efficacy against cell lines derived from high-risk SHH-TP53-mutated and MYC-amplified Non-WNT/Non-SHH medulloblastoma. vandetanib 178-188 tumor protein p53 Homo sapiens 4-8 28159923-2 2017 SHH-TP53-mutated as well as MYC-amplified Non-WNT/Non-SHH medulloblastoma show the worst prognosis.Here we present evidence that single application of the multi-kinase inhibitor Vandetanib displays anti-neoplastic efficacy against cell lines derived from high-risk SHH-TP53-mutated and MYC-amplified Non-WNT/Non-SHH medulloblastoma. vandetanib 178-188 tumor protein p53 Homo sapiens 269-273 28159923-4 2017 In this context our investigation documents that Vandetanib in combination with the clinically available PI3K inhibitor GDC-0941 leads to enhanced cytotoxicity against MYC-amplified and SHH-TP53-mutated medulloblastoma. vandetanib 49-59 tumor protein p53 Homo sapiens 190-194 28159923-7 2017 Of note, the combination of Vandetanib, GDC-0941 and Etoposide results in MYC-amplified and SHH-TP53-mutated cell lines in complete loss of cell viability. vandetanib 28-38 tumor protein p53 Homo sapiens 96-100 24138843-8 2013 ZD6474 inhibited cyclin E expression and induced p53 expression when combined with UV-B. vandetanib 0-6 tumor protein p53 Homo sapiens 49-52 20665703-6 2011 ZD6474 inhibited cyclin D1 and cyclin E expression and induced p53 expression when combined with paclitaxel. vandetanib 0-6 tumor protein p53 Homo sapiens 63-66