PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26050198-3	2015	The data demonstrated that ZD6474 inhibited the growth of osteosarcoma cells, and promoted G1-phase cell cycle arrest and apoptosis by inhibiting the activity of EGFR tyrosine kinase, and consequently suppressing its downstream PI3k/Akt and MAPK/ERK pathway.	vandetanib	27-33	mitogen-activated protein kinase 1	Homo sapiens	246-249	
26050198-6	2015	The possible molecular mechanisms to address the synergism are likely that ZD6474 induces the down-regulation of COX-2 expression through inhibiting ERK phosphorylation, while celecoxib promotes ZD6474-directed inhibition of ERK phosphorylation.	vandetanib	75-81	mitogen-activated protein kinase 1	Homo sapiens	149-152	
21970874-6	2011	Vandetanib significantly downregulated epidermal growth factor receptor (EGFR)/Erk/Akt phosphorylation as well as E2F-1 mRNA and TS mRNA/protein levels.	vandetanib	0-10	mitogen-activated protein kinase 1	Homo sapiens	79-82	
16995874-3	2006	ZD6474 induced growth arrest and apoptosis of GIST-T1 cells in association with blockade of c-Kit and its downstream effectors, including Akt and extracellular signal-regulated kinase (ERK).	vandetanib	0-6	mitogen-activated protein kinase 1	Homo sapiens	146-183	
16995874-3	2006	ZD6474 induced growth arrest and apoptosis of GIST-T1 cells in association with blockade of c-Kit and its downstream effectors, including Akt and extracellular signal-regulated kinase (ERK).	vandetanib	0-6	mitogen-activated protein kinase 1	Homo sapiens	185-188	
16995874-4	2006	ZD6474 treatment also blocked the mammalian target of rapamycin (mTOR), which lies downstream of Akt and ERK.	vandetanib	0-6	mitogen-activated protein kinase 1	Homo sapiens	105-108	
30210625-11	2018	In colon cancer PDCs with NCOA4-RET fusion, vandetanib potently inhibited AKT and ERK phosphorylation.	vandetanib	44-54	mitogen-activated protein kinase 1	Homo sapiens	82-85