PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30210625-11 2018 In colon cancer PDCs with NCOA4-RET fusion, vandetanib potently inhibited AKT and ERK phosphorylation. vandetanib 44-54 mitogen-activated protein kinase 1 Homo sapiens 82-85 21970874-6 2011 Vandetanib significantly downregulated epidermal growth factor receptor (EGFR)/Erk/Akt phosphorylation as well as E2F-1 mRNA and TS mRNA/protein levels. vandetanib 0-10 mitogen-activated protein kinase 1 Homo sapiens 79-82 16995874-3 2006 ZD6474 induced growth arrest and apoptosis of GIST-T1 cells in association with blockade of c-Kit and its downstream effectors, including Akt and extracellular signal-regulated kinase (ERK). vandetanib 0-6 mitogen-activated protein kinase 1 Homo sapiens 146-183 16995874-3 2006 ZD6474 induced growth arrest and apoptosis of GIST-T1 cells in association with blockade of c-Kit and its downstream effectors, including Akt and extracellular signal-regulated kinase (ERK). vandetanib 0-6 mitogen-activated protein kinase 1 Homo sapiens 185-188 16995874-4 2006 ZD6474 treatment also blocked the mammalian target of rapamycin (mTOR), which lies downstream of Akt and ERK. vandetanib 0-6 mitogen-activated protein kinase 1 Homo sapiens 105-108 26050198-3 2015 The data demonstrated that ZD6474 inhibited the growth of osteosarcoma cells, and promoted G1-phase cell cycle arrest and apoptosis by inhibiting the activity of EGFR tyrosine kinase, and consequently suppressing its downstream PI3k/Akt and MAPK/ERK pathway. vandetanib 27-33 mitogen-activated protein kinase 1 Homo sapiens 246-249 26050198-6 2015 The possible molecular mechanisms to address the synergism are likely that ZD6474 induces the down-regulation of COX-2 expression through inhibiting ERK phosphorylation, while celecoxib promotes ZD6474-directed inhibition of ERK phosphorylation. vandetanib 75-81 mitogen-activated protein kinase 1 Homo sapiens 149-152