PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12932292-1	2003	A synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), has been reported to have anti-inflammatory properties and to decrease the interleukin-1 (IL-1)-induced expression of matrix metalloproteinase-1 (MMP-1) and MMP-13.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	26-70	interleukin 1 alpha	Homo sapiens	154-173	
12932292-1	2003	A synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO), has been reported to have anti-inflammatory properties and to decrease the interleukin-1 (IL-1)-induced expression of matrix metalloproteinase-1 (MMP-1) and MMP-13.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	72-76	interleukin 1 alpha	Homo sapiens	154-173	
12932292-3	2003	To quantify the effects of CDDO on IL-1-induced MMP-1, MMP-13 and Bcl-3 expression, we stimulated the chondrosarcoma cell line SW-1353 and human primary chondrocytes with IL-1, in the presence or absence of CDDO.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	27-31	interleukin 1 alpha	Homo sapiens	35-39	
12932292-5	2003	In SW-1353 cells, 300 nM CDDO significantly decreased the induction of MMP-1 and MMP-13 by IL-1.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	25-29	interleukin 1 alpha	Homo sapiens	91-95	
12932292-6	2003	In human primary chondrocytes, 300 nM CDDO inhibited the induction of these genes by IL-1 to an even greater extent.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	38-42	interleukin 1 alpha	Homo sapiens	85-89	
12932292-8	2003	In human primary chondrocytes, IL-1-induced Bcl-3 expression was inhibited when cells were pretreated with CDDO.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	107-111	interleukin 1 alpha	Homo sapiens	31-35	
12932292-11	2003	Furthermore, overexpressed Bcl-3 could sustain the CDDO-dependent inhibition of IL-1-induced MMP-1 expression.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	51-55	interleukin 1 alpha	Homo sapiens	80-84	
12932292-12	2003	Our data demonstrate that CDDO inhibits IL-1-induced MMP-1 and MMP-13 expression in human chondrocytes.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	26-30	interleukin 1 alpha	Homo sapiens	40-44	
12932292-13	2003	CDDO also inhibits the expression of Bcl-3, an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	0-4	interleukin 1 alpha	Homo sapiens	47-51