PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34052981-0 2021 The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLpro)-preliminary molecular docking analysis. Levofloxacin 87-99 transmembrane serine protease 2 Homo sapiens 153-160 34052981-3 2021 METHODS: In the present study molecular docking technique was applied to test binding affinity of ciprofloxacin and levofloxacin-two commercially available fluoroquinolones, to SARS-CoV-2 S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLPRO). Levofloxacin 116-128 transmembrane serine protease 2 Homo sapiens 199-206 34052981-6 2021 In the case of TMPRSS2 protein and PLPRO protease the best docked ligand was levofloxacin and in the case of E proteins and RNA-dependent RNA polymerase the best docked ligands were levofloxacin and dexamethasone. Levofloxacin 77-89 transmembrane serine protease 2 Homo sapiens 15-22 34052981-7 2021 Moreover, a molecular dynamics study also reveals that ciprofloxacin and levofloxacin form a stable complex with E- and TMPRSS2 proteins, RNA polymerase and papain-like protease (PLPRO). Levofloxacin 73-85 transmembrane serine protease 2 Homo sapiens 120-127