PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34461908-0 2021 The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer. avasimibe 41-50 E2F transcription factor 1 L homeolog Xenopus laevis 106-111 34461908-12 2021 Moreover, E2F-1 was elevated after treatment with avasimibe. avasimibe 50-59 E2F transcription factor 1 L homeolog Xenopus laevis 10-15 34461908-13 2021 After knockdown of E2F-1 expression, the inhibition of cell proliferation and migration caused by avasimibe was significantly recovered. avasimibe 98-107 E2F transcription factor 1 L homeolog Xenopus laevis 19-24 34461908-15 2021 Immunofluorescence staining revealed lower levels of Ki67 and higher levels of E2F-1 in tumour tissues of the avasimibe group than those of the control group. avasimibe 110-119 E2F transcription factor 1 L homeolog Xenopus laevis 79-84 34461908-18 2021 CONCLUSIONS: Our results suggest that avasimibe can suppress tumour proliferation and metastasis via the E2F-1 signalling pathway. avasimibe 38-47 E2F transcription factor 1 L homeolog Xenopus laevis 105-110