PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17504756-5	2007	However, embryos null for protein O-fucosyltransferase 1, the enzyme that adds O-fucose to EGF repeats, do not exhibit a Cripto null phenotype and die at about embryonic day 9.5.	o-fucose	79-87	protein O-fucosyltransferase 1	Mus musculus	26-56	
31209283-6	2019	As Notch signaling receptors can be modified with O-fucose by Pofut1, we further showed that Cav-1-induced upregulation of Pofut1 expression activated the Notch pathway and thus enhanced invasion and metastasis by mouse HCC cells in vitro and in vivo.	o-fucose	50-58	protein O-fucosyltransferase 1	Mus musculus	62-68	
31209283-6	2019	As Notch signaling receptors can be modified with O-fucose by Pofut1, we further showed that Cav-1-induced upregulation of Pofut1 expression activated the Notch pathway and thus enhanced invasion and metastasis by mouse HCC cells in vitro and in vivo.	o-fucose	50-58	protein O-fucosyltransferase 1	Mus musculus	123-129	
29095923-3	2017	Protein O-fucosyltransferase1 (Pofut1), which transfers O-fucose to the EGF domains of the Notch1 receptor, is indispensable for Notch signaling activation.	o-fucose	56-64	protein O-fucosyltransferase 1	Mus musculus	0-29	
29095923-3	2017	Protein O-fucosyltransferase1 (Pofut1), which transfers O-fucose to the EGF domains of the Notch1 receptor, is indispensable for Notch signaling activation.	o-fucose	56-64	protein O-fucosyltransferase 1	Mus musculus	31-37	
35623385-2	2022	The addition of O-fucose by Protein O-fucosyltransferase 1 (POFUT1) to Epidermal Growth Factor-like (EGF) repeats in the N1 extracellular domain is essential for N1 function, and modification of O-fucose with GlcNAc by the Fringe family of glycosyltransferases modulates Notch activity.	o-fucose	16-24	protein O-fucosyltransferase 1	Mus musculus	28-58	
35623385-2	2022	The addition of O-fucose by Protein O-fucosyltransferase 1 (POFUT1) to Epidermal Growth Factor-like (EGF) repeats in the N1 extracellular domain is essential for N1 function, and modification of O-fucose with GlcNAc by the Fringe family of glycosyltransferases modulates Notch activity.	o-fucose	16-24	protein O-fucosyltransferase 1	Mus musculus	60-66	
35623385-2	2022	The addition of O-fucose by Protein O-fucosyltransferase 1 (POFUT1) to Epidermal Growth Factor-like (EGF) repeats in the N1 extracellular domain is essential for N1 function, and modification of O-fucose with GlcNAc by the Fringe family of glycosyltransferases modulates Notch activity.	o-fucose	195-203	protein O-fucosyltransferase 1	Mus musculus	28-58	
35623385-2	2022	The addition of O-fucose by Protein O-fucosyltransferase 1 (POFUT1) to Epidermal Growth Factor-like (EGF) repeats in the N1 extracellular domain is essential for N1 function, and modification of O-fucose with GlcNAc by the Fringe family of glycosyltransferases modulates Notch activity.	o-fucose	195-203	protein O-fucosyltransferase 1	Mus musculus	60-66	
35623385-3	2022	Prior cell-based studies showed that POFUT1 modifies EGF repeats containing the appropriate consensus sequence at high stoichiometry, while Fringe GlcNAc-transferases (LFNG, MFNG and RFNG) modify O-fucose on only a subset of N1 EGF repeats.	o-fucose	196-204	protein O-fucosyltransferase 1	Mus musculus	37-43	
32872229-4	2020	In the monophyletic group of gnathostomes, we showed that the consensus sequence for O-fucose modification by Pofut1 is highly conserved in Wif1 EGF-LD III while it was more divergent in EGF-LD V. Using click chemistry and mass spectrometry, we demonstrated that mouse WIF1 was only modified with a non-extended O-fucose on its EGF-LD III.	o-fucose	85-93	protein O-fucosyltransferase 1	Mus musculus	110-116	
32872229-4	2020	In the monophyletic group of gnathostomes, we showed that the consensus sequence for O-fucose modification by Pofut1 is highly conserved in Wif1 EGF-LD III while it was more divergent in EGF-LD V. Using click chemistry and mass spectrometry, we demonstrated that mouse WIF1 was only modified with a non-extended O-fucose on its EGF-LD III.	o-fucose	312-320	protein O-fucosyltransferase 1	Mus musculus	110-116	
32872229-6	2020	Based on sequence comparison and automated protein modeling, we suggest that the absence of O-fucose on EGF-LD V of WIF1 in mouse and probably in most gnathostomes, could be related to EGF-LD V inability to interact with POFUT1.	o-fucose	92-100	protein O-fucosyltransferase 1	Mus musculus	221-227