PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25120662-3 2014 Following treatment with 1 mumol/l shikonin for 48 h and 2.5 and 5 mumol/l shikonin for 24 and 48 h, the viability of the BXPC-3 cells was found to be significantly reduced and the protein expression of LC3-II/LC3-I was observed to be increased, while the protein expression of p62, PI3K, Akt, p-PI3K and p-Akt was decreased. shikonin 35-43 nucleoporin 62 Homo sapiens 278-281 25120662-3 2014 Following treatment with 1 mumol/l shikonin for 48 h and 2.5 and 5 mumol/l shikonin for 24 and 48 h, the viability of the BXPC-3 cells was found to be significantly reduced and the protein expression of LC3-II/LC3-I was observed to be increased, while the protein expression of p62, PI3K, Akt, p-PI3K and p-Akt was decreased. shikonin 75-83 nucleoporin 62 Homo sapiens 278-281 32461113-0 2020 Shikonin suppresses trophoblast cell growth via regulation of GLI1, and p62 mediated caspase 8activation. shikonin 0-8 nucleoporin 62 Homo sapiens 72-75 32461113-5 2020 Shikonin blocked autophagic flux and promoted p62 interaction with caspase 8, resulting in caspase 8 activation. shikonin 0-8 nucleoporin 62 Homo sapiens 46-49 32461113-9 2020 In conclusion, shikonin suppressed trophoblast cell growth by silencing GLI1 and increasing p62 co-mediated activation of caspase 8, which suggested a potential novel therapeutic target for UEP. shikonin 15-23 nucleoporin 62 Homo sapiens 92-95 34829701-10 2021 Moreover, light chain 3B (LC3B)-II accumulation and enhanced p62 expression indicated that autophagy occurred in the shikonin-treated group. shikonin 117-125 nucleoporin 62 Homo sapiens 61-64