PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32461113-0	2020	Shikonin suppresses trophoblast cell growth via regulation of GLI1, and p62 mediated caspase 8activation.	shikonin	0-8	nucleoporin 62	Homo sapiens	72-75	
32461113-5	2020	Shikonin blocked autophagic flux and promoted p62 interaction with caspase 8, resulting in caspase 8 activation.	shikonin	0-8	nucleoporin 62	Homo sapiens	46-49	
32461113-9	2020	In conclusion, shikonin suppressed trophoblast cell growth by silencing GLI1 and increasing p62 co-mediated activation of caspase 8, which suggested a potential novel therapeutic target for UEP.	shikonin	15-23	nucleoporin 62	Homo sapiens	92-95	
25120662-3	2014	Following treatment with 1 mumol/l shikonin for 48 h and 2.5 and 5 mumol/l shikonin for 24 and 48 h, the viability of the BXPC-3 cells was found to be significantly reduced and the protein expression of LC3-II/LC3-I was observed to be increased, while the protein expression of p62, PI3K, Akt, p-PI3K and p-Akt was decreased.	shikonin	35-43	nucleoporin 62	Homo sapiens	278-281	
25120662-3	2014	Following treatment with 1 mumol/l shikonin for 48 h and 2.5 and 5 mumol/l shikonin for 24 and 48 h, the viability of the BXPC-3 cells was found to be significantly reduced and the protein expression of LC3-II/LC3-I was observed to be increased, while the protein expression of p62, PI3K, Akt, p-PI3K and p-Akt was decreased.	shikonin	75-83	nucleoporin 62	Homo sapiens	278-281	
34829701-10	2021	Moreover, light chain 3B (LC3B)-II accumulation and enhanced p62 expression indicated that autophagy occurred in the shikonin-treated group.	shikonin	117-125	nucleoporin 62	Homo sapiens	61-64