PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32990238-11	2020	In both I-10 and TCAM cells, shikonin treatment significantly down- regulated the expressions of Bax, Bcl-2, cleaved caspase-3, PKM2, GLUT1 and HK2, and up-regulated the expression of autophagy-related protein LC3B (P < 0.05).	shikonin	29-37	caspase 3	Mus musculus	117-126	
33978226-10	2021	The inhibition of PKM2 by shikonin notably suppressed the expression of HIF-1alpha and apoptosis-related factors such as BNIP3, Bax, and Caspase-3, while the inhibition of PKM2 by shikonin significantly improved the histopathological symptoms of LPS-induced AKI.	shikonin	26-34	caspase 3	Mus musculus	137-146	
33313945-6	2021	Furthermore, Shikonin promoted neutrophil apoptosis by increasing the activation of caspase-3 and reducing the expression of the antiapoptotic myeloid cell leukemia-1 (Mcl-1) protein.	shikonin	13-21	caspase 3	Mus musculus	84-93	
33313945-8	2021	The findings of the present study demonstrated that shikonin protected against LTA-induced ALI by promoting caspase-3 and Mcl-1-related neutrophil apoptosis, suggesting that shikonin is a potential agent that can be used in the treatment of sepsis-mediated lung injury.	shikonin	52-60	caspase 3	Mus musculus	108-117	
33313945-8	2021	The findings of the present study demonstrated that shikonin protected against LTA-induced ALI by promoting caspase-3 and Mcl-1-related neutrophil apoptosis, suggesting that shikonin is a potential agent that can be used in the treatment of sepsis-mediated lung injury.	shikonin	174-182	caspase 3	Mus musculus	108-117