PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34600581-8	2021	The effect of shikonin on expression of interleukin-6, interleukin-1beta and tumor necrosis factor-alpha was measured by enzyme linked immunosorbent assay.	shikonin	14-22	interleukin 6	Mus musculus	40-53	
34600581-13	2021	Meanwhile, shikonin suppressed tumor necrosis factor-alpha-induced invasion, adhesion and migration of fibroblast like synoviocytes and reduced the expression of interleukin-6, interleukin-1beta and tumor necrosis factor-alpha.	shikonin	11-19	interleukin 6	Mus musculus	162-175	
32279045-6	2020	Furthermore, western blotting and the results of morphological analysis revealed that shikonin treatments markedly reduced D-gal induced neuroinflammation through inhibition of astrocytosis as determined by glial fibrillary acidic protein (GFAP) detection, and downregulating other inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and IL-6.	shikonin	86-94	interleukin 6	Mus musculus	391-395	
30818140-9	2019	Furthermore, shikonin markedly attenuated the APAP-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) and suppressed the expression of genes related to inflammation.	shikonin	13-21	interleukin 6	Mus musculus	114-127	
30818140-9	2019	Furthermore, shikonin markedly attenuated the APAP-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) and suppressed the expression of genes related to inflammation.	shikonin	13-21	interleukin 6	Mus musculus	129-133	
23651796-5	2013	Furthermore, shikonin significantly reduced the concentrations of TNF-alpha, IL-6 and IL-1beta in bronchoalveolar lavage fluid induced by LPS.	shikonin	13-21	interleukin 6	Mus musculus	77-81	
33313945-5	2021	Following shikonin treatment, the accumulation of pulmonary neutrophils and expression of TNFalpha, IL-1beta and IL-6 were decreased in mice with LTA-induced ALI.	shikonin	10-18	interleukin 6	Mus musculus	113-117	
23201088-7	2013	RESULTS: Shikonin administration significantly reduced serum amylase and lipase activities, pancreatic histological scores, TNF-alpha, IL-1beta, IL-6 levels, MPO activity and NF-kappaB activity.	shikonin	9-17	interleukin 6	Mus musculus	145-149