PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28322323-6	2017	In eye tissue, administration of shikonin also attenuated DM/hypoxia-induced pre-apoptotic protein BAX expression as well as the production of inflammatory proteins cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	shikonin	33-41	prostaglandin-endoperoxide synthase 2	Mus musculus	165-181	
28322323-6	2017	In eye tissue, administration of shikonin also attenuated DM/hypoxia-induced pre-apoptotic protein BAX expression as well as the production of inflammatory proteins cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	shikonin	33-41	prostaglandin-endoperoxide synthase 2	Mus musculus	183-188	
25767678-3	2015	Shikonin dose-dependently inhibits the expression of the proinflammatory mediators, nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor-alpha (TNF-alpha) as well as their main regulatory genes and products such as inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-alpha in LPS-stimulated BV2 microglial cells.	shikonin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	262-278	
25767678-3	2015	Shikonin dose-dependently inhibits the expression of the proinflammatory mediators, nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor-alpha (TNF-alpha) as well as their main regulatory genes and products such as inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-alpha in LPS-stimulated BV2 microglial cells.	shikonin	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	280-285	
23158409-10	2013	In addition, shikonin pretreatment significantly suppressed LPS-induced activation of cyclooxygenase 2 and inducible nitric oxide synthase and the nuclear factor kappaB DNA-binding activity in lung tissues.	shikonin	13-21	prostaglandin-endoperoxide synthase 2	Mus musculus	86-102