PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31752383-5	2019	Thus, the current study intends to discover novel shikonin derivatives which can sensitize the liver cancer cell to TRAIL-induced apoptosis while exhibiting little toxicity toward the normal hepatic cell.	shikonin	50-58	TNF superfamily member 10	Homo sapiens	116-121	
31752383-7	2019	Herein, we demonstrated that non-cytotoxic doses of acetylshikonin (ASH), one of the shikonin derivatives, in combination with TRAIL, could promote apoptosis in HepG2 cells.	shikonin	58-66	TNF superfamily member 10	Homo sapiens	127-132	
28662515-0	2017	TRAIL Enhances Shikonin Induced Apoptosis through ROS/JNK Signaling in Cholangiocarcinoma Cells.	shikonin	15-23	TNF superfamily member 10	Homo sapiens	0-5	
28662515-6	2017	RESULTS: Shikonin inhibited cell viability and induced apoptosis of CCA cells, effects enhanced by TRAIL treatment via activation of caspase-3, -8, -9.	shikonin	9-17	TNF superfamily member 10	Homo sapiens	99-104	
28662515-9	2017	CONCLUSIONS: Our results revealed that shikonin could inhibit cells viability and induce apoptosis of CCA cells, effects enhanced by TRAIL treatment via ROS mediated JNK signalling pathways, involving up-regulation of DR5 expression.	shikonin	39-47	TNF superfamily member 10	Homo sapiens	133-138	
30594131-8	2018	CONCLUSIONS: In conclusion, the results indicated that shikonin sensitized resistant cancer cells to TRAIL-induced cytotoxicity via the modulation of the JNK, STAT3 and AKT pathways, the downregulation of antiapoptotic proteins and the upregulation of proapoptotic proteins.	shikonin	55-63	TNF superfamily member 10	Homo sapiens	101-106