PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24905636-7	2014	In addition, shikonin significantly decreased the phosphorylation of AKT and mTOR in a dose-dependent manner while it induced extracellular signal-regulated kinase (ERK), p38 mitogen activated protein kinase (MAPK) and c-Jun N terminal kinase (JNK) phosphorylation.	shikonin	13-21	mitogen-activated protein kinase 1	Homo sapiens	126-163	
33164437-7	2020	Shikonin also significantly reduced the TNF-alpha-induced migration, adhesion, invasion and phosphorylation levels of Akt, JNK, p38, ERK in MH7 A cells within 24 h. These results suggested that shikonin could reduce the proliferation, migration, adhesion and invasion ability of MH7 A cells induced by TNF-alpha, and its mechanism may be related to the down-regulation of Akt and MAPK signaling pathway activation.	shikonin	0-8	mitogen-activated protein kinase 1	Homo sapiens	133-136	
33164437-7	2020	Shikonin also significantly reduced the TNF-alpha-induced migration, adhesion, invasion and phosphorylation levels of Akt, JNK, p38, ERK in MH7 A cells within 24 h. These results suggested that shikonin could reduce the proliferation, migration, adhesion and invasion ability of MH7 A cells induced by TNF-alpha, and its mechanism may be related to the down-regulation of Akt and MAPK signaling pathway activation.	shikonin	0-8	mitogen-activated protein kinase 1	Homo sapiens	380-384	
33164437-7	2020	Shikonin also significantly reduced the TNF-alpha-induced migration, adhesion, invasion and phosphorylation levels of Akt, JNK, p38, ERK in MH7 A cells within 24 h. These results suggested that shikonin could reduce the proliferation, migration, adhesion and invasion ability of MH7 A cells induced by TNF-alpha, and its mechanism may be related to the down-regulation of Akt and MAPK signaling pathway activation.	shikonin	194-202	mitogen-activated protein kinase 1	Homo sapiens	133-136	
33164437-7	2020	Shikonin also significantly reduced the TNF-alpha-induced migration, adhesion, invasion and phosphorylation levels of Akt, JNK, p38, ERK in MH7 A cells within 24 h. These results suggested that shikonin could reduce the proliferation, migration, adhesion and invasion ability of MH7 A cells induced by TNF-alpha, and its mechanism may be related to the down-regulation of Akt and MAPK signaling pathway activation.	shikonin	194-202	mitogen-activated protein kinase 1	Homo sapiens	380-384	
31545985-9	2019	In addition, shikonin downregulated the EGFR and p-ERK expression in MCF-7 and SK-BR-3, which was also not affected by the estrogen environment.	shikonin	13-21	mitogen-activated protein kinase 1	Homo sapiens	51-54	
32581812-3	2020	Mechanistically, we show that Shikonin arrested the cell cycle at the G2/M phase, inhibited the ERK-dependent cell growth signal, and induced cell death in both P53 wild type and mutant cancer cells, which collectively contributed to the growth inhibitory effect of Shikonin.	shikonin	30-38	mitogen-activated protein kinase 1	Homo sapiens	96-99	
26935874-0	2016	Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.	shikonin	0-8	mitogen-activated protein kinase 1	Homo sapiens	65-68	
24905636-7	2014	In addition, shikonin significantly decreased the phosphorylation of AKT and mTOR in a dose-dependent manner while it induced extracellular signal-regulated kinase (ERK), p38 mitogen activated protein kinase (MAPK) and c-Jun N terminal kinase (JNK) phosphorylation.	shikonin	13-21	mitogen-activated protein kinase 1	Homo sapiens	165-168	
24962386-11	2014	Shikonin effectively inhibited the phosphorylation of ERK, while it activated the phosphorylation of JNK and p38.	shikonin	0-8	mitogen-activated protein kinase 1	Homo sapiens	54-57	
15899123-10	2005	CONCLUSION: Shikonin induces HeLa cell apoptosis through the ERK, p53 and caspase pathways.	shikonin	12-20	mitogen-activated protein kinase 1	Homo sapiens	61-64	
20460760-0	2010	Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells.	shikonin	0-8	mitogen-activated protein kinase 1	Homo sapiens	59-96	
20460760-5	2010	A significantly elicited hypodiploid cell population was found in cells treated with 2, 4, and 8microM shikonin for 24 h. Moreover, treatment with shikonin induced reactive oxygen species (ROS) generation, increased extracellular signal-regulated kinase (ERK) phosphorylation, decreased B-cell lymphoma-2 (Bcl2) expression, and was accompanied by poly(ADP-ribose) polymerase (PARP) cleavage.	shikonin	103-111	mitogen-activated protein kinase 1	Homo sapiens	255-258