PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25880237-10	2015	CONCLUSIONS: The results indicated that Shikonin could suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-kappaB-mediated pathway.	shikonin	40-48	nuclear factor kappa B subunit 1	Homo sapiens	159-168	
33505807-10	2021	SK and its derivatives inhibited the activation of nucleotide binding oligomerization domain-like receptors (NLRP3) inflammasome and NF-kappaB signaling pathway, thereby relieving the DSS-induced disruption of epithelial tight junction (TJ) in colonic tissues.	shikonin	0-2	nuclear factor kappa B subunit 1	Homo sapiens	133-142	
34646528-0	2021	Shikonin protects against lipopolysaccharide-induced inflammation and apoptosis in human nucleus pulposus cells through the nuclear factor-kappa B pathway.	shikonin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	124-146	
34646528-11	2021	Furthermore, shikonin treatment significantly inhibited the expression of p-P65 and nuclear translocation of P65, and nuclear factor-kappa B (NF-kappaB) pathway inhibitor Pyrrolidinedithiocarbamate ammonium (PDTC) significantly enhanced the anti-inflammatory and antiapoptotic effects of shikonin in LPS-induced NP cells.	shikonin	288-296	nuclear factor kappa B subunit 1	Homo sapiens	118-140	
34646528-11	2021	Furthermore, shikonin treatment significantly inhibited the expression of p-P65 and nuclear translocation of P65, and nuclear factor-kappa B (NF-kappaB) pathway inhibitor Pyrrolidinedithiocarbamate ammonium (PDTC) significantly enhanced the anti-inflammatory and antiapoptotic effects of shikonin in LPS-induced NP cells.	shikonin	288-296	nuclear factor kappa B subunit 1	Homo sapiens	142-151	
34646528-12	2021	Conclusion: Shikonin significantly inhibited the inflammatory response and apoptosis of human primary NP cells, possibly through the NF-kappaB pathway.	shikonin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	133-142	
25720435-6	2015	As anticipated AG1478 (EGFR inhibitor) and Bay11-7082 (NF-kappaB inhibitor) blocked EGF-reversed the inactivation of NF-kappaB induced by shikonin.	shikonin	138-146	nuclear factor kappa B subunit 1	Homo sapiens	55-64	
25720435-6	2015	As anticipated AG1478 (EGFR inhibitor) and Bay11-7082 (NF-kappaB inhibitor) blocked EGF-reversed the inactivation of NF-kappaB induced by shikonin.	shikonin	138-146	nuclear factor kappa B subunit 1	Homo sapiens	117-126	
25720435-0	2015	Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR-NF-kappaB signalling pathway in human epidermoid carcinoma A431 cells.	shikonin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	79-88	
22011623-6	2011	However, downregulation of Akt and RIP1/NF-kappaB activity was found to be involved in shikonin-induced apoptosis.	shikonin	87-95	nuclear factor kappa B subunit 1	Homo sapiens	40-49	
25720435-4	2015	In addition, shikonin evidently induced apoptosis due to decreasing Bcl-2 expression, increasing Bax expression, activating caspase and inactivating NF-kappaB, while pretreatment with a pan-caspase inhibitor Z-Asp-CH2-DCB abrogated shikonin-induced apoptosis.	shikonin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	149-158	
25720435-5	2015	Moreover, EGF could significantly increase the NF-kappaB DNA-binding activity and reversed the shikonin-induced inactivation of NF-kappaB.	shikonin	95-103	nuclear factor kappa B subunit 1	Homo sapiens	128-137	
25541286-0	2015	Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFkappaB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA.hy926 endothelial cells.	shikonin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	72-80	
25541286-5	2015	In the presence of oxLDL (40 mug/ml), shikonin pretreatment reversed oxLDL-induced ROS production, antioxidant response element reporter activity, NFkappaB nuclear translocation, and intercellular adhesion molecule (ICAM)-1 and E-selectin expression and suppressed the increase of monocyte adhesion to endothelial cells.	shikonin	38-46	nuclear factor kappa B subunit 1	Homo sapiens	147-155	
25541286-7	2015	Taken together, these results suggest that shikonin protects against oxLDL-induced endothelial damage by suppressing ROS/NFkappaB-mediated ICAM-1 and E-selectin expression via up-regulation of PI3K/Akt/Nrf2-dependent antioxidant enzyme expression.	shikonin	43-51	nuclear factor kappa B subunit 1	Homo sapiens	121-129	
22011623-8	2011	ROS scavengers blocked shikonin-induced inactivation of Akt and RIP1/NF-kappaB, but Akt or RIP1/NF-kappaB did not regulate ROS generation, suggesting that Akt and RIP1/NF-kappaB signals are downstream of ROS generation.	shikonin	23-31	nuclear factor kappa B subunit 1	Homo sapiens	69-78