PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28933271-2	2018	OBJECTIVE: Here, it has been tried to evaluate the effects of Shikonin, a naphthoquinone derivative of Lithospermum erythrorhizon, on the induction of necroptosis and apoptosis mediated by RIPK1-RIPK3 in the ER+ breast cancer cell line, MCF-7.	shikonin	62-70	receptor interacting serine/threonine kinase 3	Homo sapiens	195-200	
31118661-0	2019	Shikonin-induced necroptosis in nasopharyngeal carcinoma cells via ROS overproduction and upregulation of RIPK1/RIPK3/MLKL expression.	shikonin	0-8	receptor interacting serine/threonine kinase 3	Homo sapiens	112-117	
31118661-12	2019	Conclusion: Shikonin induced 5-8F cell death via increased ROS production and the upregulation of RIPK1/RIPK3/MLKL expression, resulting in necroptosis.	shikonin	12-20	receptor interacting serine/threonine kinase 3	Homo sapiens	104-109	
29608987-3	2018	Further investigation revealed that shikonin-induced decreases of glucose-6-phosphate and pyruvate and downregulation of HK II and PKM2 were significantly prevented when RIP1 or RIP3 was pharmacologically inhibited or genetically knocked down with SiRNA.	shikonin	36-44	receptor interacting serine/threonine kinase 3	Homo sapiens	178-182	
29608987-7	2018	Notably, inhibition of RIP1 or RIP3 prevented intracellular H2O2 accumulation, which was correlated with preventing shikonin-induced downregulation of x-CT and depletion of GSH and cysteine.	shikonin	116-124	receptor interacting serine/threonine kinase 3	Homo sapiens	31-35	
28816233-0	2017	Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation.	shikonin	0-8	receptor interacting serine/threonine kinase 3	Homo sapiens	91-95	
29312502-0	2017	Shikonin induces apoptosis and necroptosis in pancreatic cancer via regulating the expression of RIP1/RIP3 and synergizes the activity of gemcitabine.	shikonin	0-8	receptor interacting serine/threonine kinase 3	Homo sapiens	102-106	
28816233-5	2017	Moreover, shikonin treatment dose-dependently upregulated the levels of RIP1 and RIP3 and reinforced their interaction in the glioma cells.	shikonin	10-18	receptor interacting serine/threonine kinase 3	Homo sapiens	81-85	
24314238-11	2013	After 8-hour treatment of shikonin, the expression levels of RIP1 and RIP3 were increased while caspase-3, caspase-6 and PARP were not activated in K7 and U2OS cells determined by Western blot.	shikonin	26-34	receptor interacting serine/threonine kinase 3	Homo sapiens	70-74	
31560934-7	2019	Then, we found that RIP3 accounts for shikonin-induced activation of MLKL, and activated MLKL reversely up-regulates the protein level of CYLD and promotes the activation of RIP1 and RIP3.	shikonin	38-46	receptor interacting serine/threonine kinase 3	Homo sapiens	20-24	
32927433-4	2020	The present study shows that shikonin, an herbal compound used in traditional Chinese medicine, overcomes TKI resistance in BCR/ABL-positive CML cells by inducing necroptosis via activation of RIPK1/RIPK3/MLKL signaling.	shikonin	29-37	receptor interacting serine/threonine kinase 3	Homo sapiens	199-204	
31560934-8	2019	Taken together, our data suggest that MLKL contributes to shikonin-induced glioma cell necroptosis via promotion of chromatinolysis, and shikonin induces a positive feedback between MLKL and its upstream signals RIP1 and RIP3.	shikonin	58-66	receptor interacting serine/threonine kinase 3	Homo sapiens	221-225	
31560934-8	2019	Taken together, our data suggest that MLKL contributes to shikonin-induced glioma cell necroptosis via promotion of chromatinolysis, and shikonin induces a positive feedback between MLKL and its upstream signals RIP1 and RIP3.	shikonin	137-145	receptor interacting serine/threonine kinase 3	Homo sapiens	221-225