PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33978226-10	2021	The inhibition of PKM2 by shikonin notably suppressed the expression of HIF-1alpha and apoptosis-related factors such as BNIP3, Bax, and Caspase-3, while the inhibition of PKM2 by shikonin significantly improved the histopathological symptoms of LPS-induced AKI.	shikonin	26-34	BCL2-associated X protein	Mus musculus	128-131	
32892382-6	2020	But, shikonin treatment significantly reduced the expression levels of TNF-alpha, IFN-gamma and Bax.	shikonin	5-13	BCL2-associated X protein	Mus musculus	96-99	
32990238-11	2020	In both I-10 and TCAM cells, shikonin treatment significantly down- regulated the expressions of Bax, Bcl-2, cleaved caspase-3, PKM2, GLUT1 and HK2, and up-regulated the expression of autophagy-related protein LC3B (P < 0.05).	shikonin	29-37	BCL2-associated X protein	Mus musculus	97-100	
28322323-6	2017	In eye tissue, administration of shikonin also attenuated DM/hypoxia-induced pre-apoptotic protein BAX expression as well as the production of inflammatory proteins cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).	shikonin	33-41	BCL2-associated X protein	Mus musculus	99-102