PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29304496-8	2018	Furthermore, shikonin also strongly decreased the levels of activated caspase-3, Bax and p-GSK-3beta while increased the p-AKT level.	shikonin	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	81-84	
34211568-15	2021	SK treatment upregulated the expression of bcl-2 and downregulated the expression of bax, thereby elevating the bcl-2/bax ratio.	shikonin	0-2	BCL2 associated X, apoptosis regulator	Rattus norvegicus	85-88	
34211568-15	2021	SK treatment upregulated the expression of bcl-2 and downregulated the expression of bax, thereby elevating the bcl-2/bax ratio.	shikonin	0-2	BCL2 associated X, apoptosis regulator	Rattus norvegicus	118-121	
25755716-10	2015	Shikonin pretreatment also decreased the activity of IL-1beta that decreased Bcl-2 expression and levels of p-PI3K and p-Akt, and increased Bax expression, cytochrome c release, and caspase-3 activation.	shikonin	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	140-143	
29311595-6	2018	Furthermore, shikonin has the ability to reduce proapoptotic signaling by reducing the activity of caspase-3 and moderating the ratio of Bcl-2/Bax.	shikonin	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	143-146