PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24905636-6	2014	Mechanically, we presented that shikonin could suppress the metastasis of PC-3 and DU145 cells via inhibiting the matrix metalloproteinase-2 (MMP-2) and MMP-9 expression and activation.	shikonin	32-40	matrix metallopeptidase 9	Homo sapiens	153-158	
26473829-12	2015	In addition, shikonin also inhibited the expression of p-PI3K and p-Akt to attenuate cell migration and invasion and MMP-2 and MMP-9 expression in both cell lines, which could be reversed by the PI3K/Akt pathway agonist, insulin-like growth factor-1 (IGF-1).	shikonin	13-21	matrix metallopeptidase 9	Homo sapiens	127-132	
24905636-9	2014	Additionally, DTT reversed the shikonin induced activation of ERK1/2, thereby maintaining MMP-2 and MMP-9 expression and restoring cell metastasis.	shikonin	31-39	matrix metallopeptidase 9	Homo sapiens	100-105	
34812264-10	2021	shRNA-TRAP1 enhanced the inhibitory effect of shikonin on matrix metalloproteinase (MMP)2 and MMP9 expression.	shikonin	46-54	matrix metallopeptidase 9	Homo sapiens	94-98	
24789371-4	2014	We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity.	shikonin	14-22	matrix metallopeptidase 9	Homo sapiens	177-203	
24789371-4	2014	We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity.	shikonin	14-22	matrix metallopeptidase 9	Homo sapiens	205-210	
24789371-5	2014	We also found that shikonin inhibited both MMP-9 expression and promoter activity in MDA-MB-231 cells with high metastatic potential.	shikonin	19-27	matrix metallopeptidase 9	Homo sapiens	43-48	
24789371-6	2014	These results indicated that shikonin induces the suppression of migration and invasion through modulation of MMP-9 in human breast cancer cells.	shikonin	29-37	matrix metallopeptidase 9	Homo sapiens	110-115	
33508949-7	2021	Moreover, Annexin V/PI assay and Transwell invasion assay results indicated that Shikonin induced apoptosis and invasion inhibitory probably due to upregulation of caspase-3 and caspase-8 expression and downregulation of MMP-9 and EGFR expression in a concentration-dependent fashion.	shikonin	81-89	matrix metallopeptidase 9	Homo sapiens	221-226	
33508949-8	2021	Shikonin could enhance apoptosis and inhibit proliferation and invasion of QBC939 cells; such biological behaviors mainly occurred via upregulating the expression of caspase-3 and caspase-8 and downregulating the expression of MMP-9 and EGFR.	shikonin	0-8	matrix metallopeptidase 9	Homo sapiens	227-232