PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32705251-3 2020 Shikonin, a natural naphthoquinone isolated from Lithospermum erythrorhizon, possesses anti-inflammatory and immunosuppressive properties and can suppress IL-17-induced vascular endothelial growth factor expression by inhibiting the JAK/STAT3 pathway. shikonin 0-8 signal transducer and activator of transcription 3 Homo sapiens 237-242 33807148-0 2021 Shikonin Derivatives from Onsoma visianii Decrease Expression of Phosphorylated STAT3 in Leukemia Cells and Exert Antitumor Activity. shikonin 0-8 signal transducer and activator of transcription 3 Homo sapiens 80-85 34234853-0 2021 Shikonin Inhibits Tumor Growth of ESCC by suppressing PKM2 mediated Aerobic Glycolysis and STAT3 Phosphorylation. shikonin 0-8 signal transducer and activator of transcription 3 Homo sapiens 91-96 34234853-10 2021 Furthermore, Shikonin not only inhibited the growth of ESCC, but also decreased the expression of p-PKM2 and p-STAT3 in vivo. shikonin 13-21 signal transducer and activator of transcription 3 Homo sapiens 111-116 34234853-12 2021 Conclusion: Shikonin has a significant antitumor effect in the ESCC by suppressing PKM2 mediated aerobic glycolysis and regulating PKM2/STAT3 signal pathway. shikonin 12-20 signal transducer and activator of transcription 3 Homo sapiens 136-141 32705271-0 2020 Shikonin blocks human lung adenocarcinoma cell migration and invasion in the inflammatory microenvironment via the IL-6/STAT3 signaling pathway. shikonin 0-8 signal transducer and activator of transcription 3 Homo sapiens 120-125 32705271-6 2020 Moreover, shikonin inhibited IL-6-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3), prevented phosphorylated STAT3 (p-STAT3) translocation into the nucleus, and suppressed p-STAT3 transactivation activity. shikonin 10-18 signal transducer and activator of transcription 3 Homo sapiens 61-111 32705271-6 2020 Moreover, shikonin inhibited IL-6-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3), prevented phosphorylated STAT3 (p-STAT3) translocation into the nucleus, and suppressed p-STAT3 transactivation activity. shikonin 10-18 signal transducer and activator of transcription 3 Homo sapiens 113-118 32705271-6 2020 Moreover, shikonin inhibited IL-6-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3), prevented phosphorylated STAT3 (p-STAT3) translocation into the nucleus, and suppressed p-STAT3 transactivation activity. shikonin 10-18 signal transducer and activator of transcription 3 Homo sapiens 146-151 32705271-6 2020 Moreover, shikonin inhibited IL-6-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3), prevented phosphorylated STAT3 (p-STAT3) translocation into the nucleus, and suppressed p-STAT3 transactivation activity. shikonin 10-18 signal transducer and activator of transcription 3 Homo sapiens 146-151 32705271-6 2020 Moreover, shikonin inhibited IL-6-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3), prevented phosphorylated STAT3 (p-STAT3) translocation into the nucleus, and suppressed p-STAT3 transactivation activity. shikonin 10-18 signal transducer and activator of transcription 3 Homo sapiens 146-151 32705271-7 2020 Additionally, it was found that shikonin inhibited lung metastasis, EMT and expression of p-STAT3 of A549 cells in vivo. shikonin 32-40 signal transducer and activator of transcription 3 Homo sapiens 92-97 32705271-9 2020 Together, these results suggest that shikonin suppresses the migration and invasion of human lung adenocarcinoma cells in an inflammatory microenvironment involving the IL-6/STAT3 signaling pathway. shikonin 37-45 signal transducer and activator of transcription 3 Homo sapiens 174-179 35328817-12 2022 Our results demonstrate for the first time that shikonin derivatives have extensive effects on the inflammatory processes, MAPKs, and IL6/STAT3 downstream regulation in healthy and OA chondrocytes. shikonin 48-56 signal transducer and activator of transcription 3 Homo sapiens 138-143 24521871-0 2014 Shikonin suppresses IL-17-induced VEGF expression via blockage of JAK2/STAT3 pathway. shikonin 0-8 signal transducer and activator of transcription 3 Homo sapiens 71-76 32536866-0 2020 Inhibition of the STAT3 Signaling Pathway Contributes to the Anti-Melanoma Activities of Shikonin. shikonin 89-97 signal transducer and activator of transcription 3 Homo sapiens 18-23 32536866-17 2020 Mechanistic study indicated that shikonin inhibited the phosphorylation and homo-dimerization of STAT3, thus reduced its nuclear localization. shikonin 33-41 signal transducer and activator of transcription 3 Homo sapiens 97-102 32536866-18 2020 Further study showed that shikonin decreased the levels of STAT3-targeted genes Mcl-1, Bcl-2, MMP-2, vimentin, and Twist, which are involved in melanoma survival, migration, and invasion. shikonin 26-34 signal transducer and activator of transcription 3 Homo sapiens 59-64 32536866-19 2020 More importantly, overexpression of constitutively active STAT3 partially abolished the anti-proliferative, anti-migratory, and anti-invasive effects of shikonin. shikonin 153-161 signal transducer and activator of transcription 3 Homo sapiens 58-63 32536866-20 2020 Conclusion: The anti-melanoma activity of shikonin is at least partially attributed to the inhibition on STAT3 signaling. shikonin 42-50 signal transducer and activator of transcription 3 Homo sapiens 105-110 31075711-4 2019 Our results showed that shikonin significantly inhibits cell proliferation and induces apoptosis in both HaCaT and LV-STAT3 HaCaT cells by targeting CEBPD, while a decrease in cell survival, proliferation and viability were found through flow-cytometry and MTS assay. shikonin 24-32 signal transducer and activator of transcription 3 Homo sapiens 118-123 30594131-7 2018 Combined treatment with shikonin and TRAIL activated the caspase and JNK pathways, inhibited the STAT3 and AKT pathways, downregulated the expression of Mcl-1, Bcl-2, Bcl-xL, c-FLIP and XIAP and upregulated the expression of Bid. shikonin 24-32 signal transducer and activator of transcription 3 Homo sapiens 97-102 30594131-8 2018 CONCLUSIONS: In conclusion, the results indicated that shikonin sensitized resistant cancer cells to TRAIL-induced cytotoxicity via the modulation of the JNK, STAT3 and AKT pathways, the downregulation of antiapoptotic proteins and the upregulation of proapoptotic proteins. shikonin 55-63 signal transducer and activator of transcription 3 Homo sapiens 159-164 24521871-8 2014 These results imply that shikonin suppresses IL-17-induced VEGF expression in vitro and in vivo and the mechanisms may be related to its effect in blockage of JAK2/STAT3 pathway. shikonin 25-33 signal transducer and activator of transcription 3 Homo sapiens 164-169