PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34521930-4	2021	The results showed that shikonin induced apoptosis and autophagy in RA-FLSs by activating the production of reactive oxygen species (ROS) and inhibiting intracellular ATP levels, glycolysis-related proteins, and the PI3K-AKT-mTOR signaling pathway.	shikonin	24-32	AKT serine/threonine kinase 1	Rattus norvegicus	221-224	
34211568-3	2021	The effects of SK treatment on the PTEN/Akt/CREB/BDNF signaling pathway and apoptosis in hippocampal neurons were examined in a rat model of VaD established via bilateral common carotid artery occlusion (BCCAO).	shikonin	15-17	AKT serine/threonine kinase 1	Rattus norvegicus	40-43	
34211568-0	2021	Shikonin Attenuates Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment by Inhibiting Apoptosis via PTEN/Akt/CREB/BDNF Signaling.	shikonin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	113-116	
34211568-11	2021	SK administration reversed the upregulation of p-PTEN and the downregulation of p-Akt, p-CREB, and BDNF.	shikonin	0-2	AKT serine/threonine kinase 1	Rattus norvegicus	82-85	
34211568-18	2021	In conclusion, SK inhibited hippocampal neuronal apoptosis to protect against CCH-induced injury by regulating the PTEN/Akt/CREB/BDNF signaling pathway, consequently improving cognitive impairment.	shikonin	15-17	AKT serine/threonine kinase 1	Rattus norvegicus	120-123	
25755716-10	2015	Shikonin pretreatment also decreased the activity of IL-1beta that decreased Bcl-2 expression and levels of p-PI3K and p-Akt, and increased Bax expression, cytochrome c release, and caspase-3 activation.	shikonin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	121-124	
35417044-11	2022	The expression of NOX4 was significantly inhibited in shikonin-treated group and the levels of phosphatidylinositol 3,4,5-trisphosphate 3-phosphate and dual specificity protein phosphate (PTEN) and p-p65 were decreased, while level of p-Akt was elevated.	shikonin	54-62	AKT serine/threonine kinase 1	Rattus norvegicus	237-240	
35417044-13	2022	Shikonin downregulated expression of NOX4, PTEN and p-p65, and upregulated p-AKT and Bcl-2 expression in HK2 cells treated with lipopolysaccharide (LPS).	shikonin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	77-80	
35417044-14	2022	Moreover, overexpression of NOX4 enhanced the effect of LPS on the expression level of PTEN, p-p65, p-AKT, and Bcl-2, which was reversed by the addition of shikonin.	shikonin	156-164	AKT serine/threonine kinase 1	Rattus norvegicus	102-105	
35417044-15	2022	Taken together, shikonin could improve sepsis-induced AKI in rats, and attenuate the LPS induced KTECs apoptosis, oxidative stress, and inflammatory reaction via modulating NOX4/PTEN/AKT pathway.	shikonin	16-24	AKT serine/threonine kinase 1	Rattus norvegicus	183-186	
32497675-0	2020	Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways.	shikonin	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	82-85	
29807220-0	2018	Shikonin protects H9C2 cardiomyocytes against hypoxia/reoxygenation injury through activation of PI3K/Akt signaling pathway.	shikonin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	102-105	
27703516-0	2016	Shikonin inhibits inflammation and chondrocyte apoptosis by regulation of the PI3K/Akt signaling pathway in a rat model of osteoarthritis.	shikonin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	83-86	
27703516-8	2016	Shikonin administration attenuated the changes in caspase-3 activity and COX-2 expression and Akt phosphorylation in rats with osteoarthritis.	shikonin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	94-97	
27703516-9	2016	These results indicate that shikonin inhibits inflammation and chondrocyte apoptosis by regulating the phosphoinositide 3-kinase/Akt signaling pathway in a rat model of osteoarthritis.	shikonin	28-36	AKT serine/threonine kinase 1	Rattus norvegicus	129-132	
25755716-12	2015	These data suggested that shikonin may protect chondrocytes from apoptosis induced by IL-1beta through the PI3K/Akt signaling pathway, by deactivating caspase-3.	shikonin	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	112-115