PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29243243-11	2018	In cultured macrophages, shikonin inhibited TLR4 signalling and pro-inflammatory cytokine production.	shikonin	25-33	toll-like receptor 4	Mus musculus	44-48	
24248858-7	2014	Compared with vehicle group, 25 mg/kg shikonin significantly improved neurological deficit, decreased infarct volume and edema both at 24 and 72 h after transient ischemic stroke, our data also showed that shikonin inhibited the pro-inflammatory mediators, including TLR4, TNF-alpha, NF-kappaB, and phosphorylation of p38MAPK in ischemic cortex.	shikonin	38-46	toll-like receptor 4	Mus musculus	267-271	
29207664-0	2017	Shikonin protects against D-Galactosamine and lipopolysaccharide-induced acute hepatic injury by inhibiting TLR4 signaling pathway.	shikonin	0-8	toll-like receptor 4	Mus musculus	108-112	
24248858-0	2014	Protective effect of shikonin in experimental ischemic stroke: attenuated TLR4, p-p38MAPK, NF-kappaB, TNF-alpha and MMP-9 expression, up-regulated claudin-5 expression, ameliorated BBB permeability.	shikonin	21-29	toll-like receptor 4	Mus musculus	74-78	
24248858-7	2014	Compared with vehicle group, 25 mg/kg shikonin significantly improved neurological deficit, decreased infarct volume and edema both at 24 and 72 h after transient ischemic stroke, our data also showed that shikonin inhibited the pro-inflammatory mediators, including TLR4, TNF-alpha, NF-kappaB, and phosphorylation of p38MAPK in ischemic cortex.	shikonin	206-214	toll-like receptor 4	Mus musculus	267-271